2008-2013年泌尿生殖道感染解脲脲支原体对抗菌药物敏感性分析

发布时间：2018-04-28 14:45

本文选题：泌尿生殖道 + 解脲脲支原体　；参考：《中华医院感染学杂志》2015年08期

【摘要】：目的分析患者泌尿生殖道感染解脲脲支原体对抗菌药物的敏感性,为临床合理使用抗菌药物提供依据。方法回顾性分析2008年1月-2013年10月妇产科、泌尿外科门诊送检的解脲脲支原体培养阳性3 280例患者的临床资料及药敏数据,采用WHONET进行统计分析。结果不同性别泌尿生殖道感染患者解脲脲支原体对米诺环素、多西环素均有很高的敏感性,敏感率90.0%;2008-2013年解脲脲支原体对左氧氟沙星、阿奇霉素、交沙霉素、罗红霉素、氧氟沙星、司帕沙星的敏感率均有下降趋势,敏感率降低13.0%~68.1%,且女性患者下降趋势更为明显;解脲脲支原体对左氧氟沙星、司帕沙星则随着年龄增长药物敏感率有明显下降趋势。结论解脲脲支原体对米诺环素、多西环素有很高的敏感性,不同性别、不同年龄患者解脲脲支原体的药物敏感率差异较大,经验用药应避免使用喹诺酮类药物,治疗时应根据药敏结果合理选用抗菌药物,以防止耐药菌株的增加和播散。
[Abstract]:Objective to analyze the sensitivity of Ureaplasma Urealyticum to antimicrobial agents in patients with urogenital tract infection. Methods the clinical data and drug sensitivity data of 3 280 cases of Ureaplasma Urealyticum culture positive were analyzed retrospectively from January 2008 to October 2013 in gynecology and obstetrics department and outpatient department of urology. WHONET was used for statistical analysis. Results Ureaplasma Urealyticum was highly sensitive to minocycline and doxycycline in patients with genitourinary tract infection. The sensitivity rate of Ureaplasma Urealyticum to levofloxacin, azithromycin, josamycin and roxithromycin was 90.0%. The sensitivity of ofloxacin and sparfloxacin decreased by 13.0% and 68.1%, and the decrease of Ureaplasma Urealyticum to levofloxacin and sparfloxacin decreased with age. Conclusion Ureaplasma Urealyticum has a high sensitivity to minocycline and doxycycline. The sensitivity rate of Ureaplasma Urealyticum to minocycline and doxycycline in patients with different genders and ages is quite different. The use of quinolones should be avoided in empirical use of Ureaplasma Urealyticum. In order to prevent the increase and spread of drug resistant strains, antimicrobial agents should be reasonably selected according to the results of drug sensitivity.
【作者单位】：解放军总医院微生物科;
【基金】：军队十二五重大基金资助项目(AWS11C001)
【分类号】：R691.3

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