哈乐联合荡石胶囊治疗输尿管中下段结石的临床研究

发布时间：2018-04-28 14:45

本文选题：输尿管中下段结石 + 哈乐　；参考：《中国现代医学杂志》2017年01期

【摘要】：目的探讨哈乐联合荡石胶囊治疗输尿管中、下段结石的临床效果及安全性。方法将128例输尿管中、下段结石患者随机分为哈乐组、荡石组和联合组3组。哈乐组43例患者,口服哈乐胶囊,0.4 mg/次,1次/d;荡石组40例患者,口服荡石胶囊,1.8g/次,3次/d;联合组45例患者同时口服哈乐及荡石胶囊。嘱3组患者多饮水,适量活动,比较3组患者4周内结石排出时间、结石排出率、肾绞痛发生率、外科干预率及不良反应发生率。结果联合组结石排出时间为(6.2±3.5)d,结石排出率为75.6%,肾绞痛发生率为13.3%,外科干预率为15.6%。其与哈乐组及荡石组比较,差异有统计学意义(P0.05)。而3组不良反应发生率比较,差异无统计学意义(P0.05)。结论哈乐联合荡石胶囊较单独用药可明显提高输尿管中、下段结石排出率,缩短排出时间,减少肾绞痛发生率和外科干预率,且未增加不良反应发生率,是治疗输尿管中、下段结石的一种安全而有效的方式,值得临床应用和推广。
[Abstract]:Objective to investigate the clinical effect and safety of Halle combined with Dangshi capsule in the treatment of middle and lower ureteral calculi. Methods 128 patients with lower ureteral calculi were randomly divided into three groups: halo group, Dangshi group and combined group. In the halo group, 43 patients were treated by oral administration of Hale capsule (0.4 mg/ d), 40 patients in Dangshi group (n = 40) by Dangshi capsule, and 45 patients in combined group (n = 45) by oral administration of Haloc and Dangshi capsules at the same time, and 40 patients in Dangshi group were treated with Dangshi capsule at the same time. Three groups of patients were asked to drink more water and exercise in moderation. The time of stone excretion, the rate of stone excretion, the incidence of renal colic, the rate of surgical intervention and the incidence of adverse reactions were compared in the three groups. Results in the combined group, the stone excretion time was 6.2 卤3.5 days, the stone excretion rate was 75.6, the incidence of renal colic was 13.3, and the surgical intervention rate was 15.6. Compared with Hale group and Dangshi group, the difference was statistically significant (P 0.05). However, there was no significant difference in the incidence of adverse reactions among the three groups (P 0.05). Conclusion Hal combined with Dengshi capsule can significantly increase the excretion rate of middle and lower ureteral calculi, shorten the excretion time, reduce the incidence of renal colic and the rate of surgical intervention, and do not increase the incidence of adverse reactions in the treatment of ureter. It is a safe and effective way for lower segment stones to be applied and popularized in clinic.
【作者单位】：中南大学湘雅医院泌尿外科;
【分类号】：R693.4

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