慢性肾炎蛋白尿临床证治优化方案的疗效研究

发布时间：2018-04-29 23:36

本文选题：慢性肾炎 + 蛋白尿　；参考：《山西中医学院学报》2014年04期

【摘要】：目的:通过观察患者运用优化后的治疗慢性肾炎蛋白尿的方案后临床症状及指标的改善,来进一步评价中医治疗慢性肾炎蛋白尿临床证治优化方案在临床中的疗效和安全性,为下一步更广范围的临床推广运用提供循证医学证据。方法:选取自2012年7月-2013年10月以来门诊及住院收治的40例慢性原发性肾炎蛋白尿患者随机分为两组。对照组10例给予氯沙坦胶囊治疗,治疗组30例在此基础上给予中医辨证治疗,两组疗程均为6个月,观察患者治疗前以及治疗6个月后的实验室指标、临床症状,比较两组患者的临床疗效及各项指标水平。结果:6个月后治疗组总有效率高于对照组,中医症候总积分高于对照组,差异具有统计学意义(P0.05,P0.01);两组病例治疗前后24 h尿蛋白定量、血肌酐、尿素氮、eGFR、Cys-C水平比较,差异无统计学意义。结论:中医辨证治疗慢性肾炎蛋白尿患者的疗效确切,能够显著改善慢性肾炎患者的临床症状与患者的肾脏功能,在服用中药期间无毒副反应,容易使患者长期接受,值得临床推广应用。
[Abstract]:Objective: to evaluate the clinical efficacy and safety of traditional Chinese medicine in the treatment of chronic glomerulonephritis proteinuria by observing the improvement of clinical symptoms and indexes after the treatment of chronic glomerulonephritis proteinuria. To provide evidence-based medical evidence for a wider range of clinical applications. Methods: from July 2012 to October 2013, 40 patients with proteinuria of chronic primary nephritis were randomly divided into two groups. The control group (n = 10) was treated with losartan capsule, and the treatment group (n = 30) was treated with TCM syndrome differentiation. The course of treatment was 6 months. The laboratory indexes and clinical symptoms were observed before and after 6 months of treatment. To compare the clinical curative effect and each index level between the two groups. Results: after 6 months, the total effective rate of the treatment group was higher than that of the control group, and the total score of TCM symptom was higher than that of the control group, and the difference was statistically significant (P 0.05), and the levels of urinary protein, serum creatinine and urea nitrogen were compared between the two groups at 24 h before and after treatment. The difference was not statistically significant. Conclusion: the treatment of chronic glomerulonephritis with proteinuria by traditional Chinese medicine is effective and can improve the clinical symptoms and renal function of patients with chronic glomerulonephritis. There is no toxic and side effect during taking Chinese medicine, and it is easy for the patients to accept it for a long time. It is worth popularizing and applying in clinic.
【作者单位】：浙江中医药大学;
【分类号】：R259

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