M受体阻滞剂联合非药物方式治疗成年女性膀胱过度活动症的系统评价

发布时间：2018-05-03 22:16

本文选题：膀胱过度活动症 + M受体阻滞剂　；参考：《重庆医科大学学报》2015年10期

【摘要】：目的:系统评价M受体阻滞剂联合非药物方式治疗成年女性膀胱过度活动症(overactive bladder,OAB)的疗效及临床价值。方法:检索2015年1月前在Pub Med、Embase、Web of Science以及相关期刊论文(CNKI)和中国生物医学文献数据库(CBWMDisc)等已公开发表的关于M受体阻滞剂联合非药物与单用M受体阻滞剂相比治疗成年女性膀胱过度活动症(OAB)的随机对照试验,通过纳入标准和排除标准筛选文献。按照Jadad量表评价纳入研究的质量,采用Revman5.3进行meta分析。结果:共有7篇文献(共610例)符合纳入标准。其中M受体阻滞剂联合电刺激4篇,联合行为训练2篇,联合电刺激加行为训练1篇。Meta分析结果显示:(1)与对照组(单用M受体阻滞剂组)相比,M受体阻滞剂联合电刺激在降低日平均排尿次数(WMD=-0.60,95%CI=-1.23~0.03,P=0.06)、尿失禁次数(SMD=-4.45,95%CI=-12.77~3.86,P=0.29)方面疗效无统计学差异;但在降低尿急次数(WMD=-1.09,95%CI=-2.15~-0.03,P=0.04),提高临床总有效率(RR=1.24,95%CI=1.06~1.44,P=0.007)方面,M受体阻滞剂联合电刺激疗效优于对照组。(2)M受体阻滞剂联合行为训练在降低日平均排尿次数方面疗效优于对照组(WMD=-0.67,95%CI=-1.14~-0.20,P=0.005)。结论:M受体阻滞剂联合非药物治疗方式较单用M受体阻滞剂能够更好地改善成年女性OAB患者的部分排尿症状,提高临床总有效率。
[Abstract]:Objective: to evaluate the efficacy and clinical value of M receptor blocker combined with non-drug therapy in the treatment of overactive bladder hyperactivity syndrome (OAB) in adult women. Methods: to search for the M receptor blockers combined with non-drugs and single M receptor blockers published before January 2015 in Pub Medbase of Science and China Journal Full-text Database (CNKI) and Chinese Biomedical Literature Database (CBWM Disc). A randomized controlled trial compared with OAB for adult women with bladder hyperactivity. The literature was screened by inclusion criteria and exclusion criteria. According to the quality of Jadad scale, Revman5.3 was used for meta analysis. Results: a total of 7 articles (610 cases) met the inclusion criteria. Among them, M receptor blockers combined with electrical stimulation (4 articles) and behavioral training (2 articles), The results of combined electrical stimulation and behavioral training 1 .Meta analysis showed that compared with the control group (M receptor blocker group) and the control group (M receptor blocker group), there was no significant difference in the effect of combined electrical stimulation with M receptor blocker on reducing the daily average urination times (WMD-0.60 ~ 95CI-1.23CI-0.03), urinary incontinence (SMD-4.455) and urinary incontinence (SMD-4.455CI-1 / 12.773.86 P0.29). However, in reducing the times of urinal urgency, WMD-1.09 ~ 95CI-2.15- 0.03P0.04, and improving the total clinical effective rate, the effect of combined electrical stimulation with RRMreceptor blocker was better than that of the control group in reducing the average daily urination times. The effect of combined action training of the group was superior to that of the control group in reducing the daily average urination times. The therapeutic effect was better than that of WMD-0.6795CI-1.14- 0.20P0.005. the effect of electrical stimulation was better than that of the control group (WMD-0.6795CI-1.14- 0.20g / kg P0. 005N) in decreasing the number of times of urination in the control group (P < 0. 05), but the effect was better than that in the control group. Conclusion compared with the single use of M-receptor blockers, the micturition symptoms of adult female patients with OAB can be improved better and the total clinical effective rate can be improved by the combination of fraction M receptor blocker and non-drug therapy.
【作者单位】：重庆医科大学附属第二医院泌尿外科;
【分类号】：R694

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