氢氧化镧对大鼠慢性肾衰高磷血症的改善作用研究

发布时间：2018-05-04 12:14

本文选题：氢氧化镧 + 慢性肾衰　；参考：《中国药房》2017年04期

【摘要】：目的:研究氢氧化镧对大鼠慢性肾衰高磷血症的改善作用。方法:取大鼠建立慢性肾衰高磷血症模型,再随机分为模型组、碳酸镧组[0.3 g/(kg·d)]、碳酸钙组[4.2 g/(kg·d)]和氢氧化镧高、中、低剂量组[1.5、1、0.5 g/(kg·d)],每组10只。同日上午继续ig腺嘌呤0.2 g/(kg·d),下午ig相应药物,1周后停止给予腺嘌呤,连续给药22 d,另取10只正常大鼠作为正常对照组。对各组小鼠进行一般检查,末次给药后检测大鼠肾脏系数,血清中钙、磷、甲状旁腺素(PTH)、肌酐、尿素氮含量,以及肾脏病理学变化。结果:与正常对照组比较,模型组大鼠呈现慢性肾衰体征,肾脏系数和磷、PTH、肌酐、尿素氮含量均增加,钙含量减少(P0.01),肾脏切片呈明显病理学特征。与模型组比较,碳酸镧组、碳酸钙组和氢氧化镧各剂量组大鼠慢性肾衰体征均改善,肾脏系数(除氢氧化镧高剂量组外)和磷(除碳酸钙组外)、PTH(除氢氧化镧低剂量组、碳酸钙组外)、肌酐(除氢氧化镧低剂量组、碳酸钙组外)、尿素氮含量均减少,钙含量和钙磷乘积(仅碳酸钙组)均增加(P0.05或P0.01),其余差异无统计学意义;肾脏切片病理学特征好转。结论:氢氧化镧可改善慢性肾衰高磷血症模型大鼠肾功能,降低血清磷含量。
[Abstract]:Objective: to study the effect of lanthanum hydroxide on hyperphosphatemia in rats with chronic renal failure. Methods: the hyperphosphatemia model of chronic renal failure was established in rats. The rats were randomly divided into three groups: model group, lanthanum carbonate group (0.3 g/(kg d), calcium carbonate group (4.2 g/(kg d) and lanthanum hydroxide high, middle and low dose groups (1.5 g/(kg / d) with 10 rats in each group. On the same day, the administration of adenine 0.2 g/(kg was continued in the morning. After 1 week of administration, adenine was given continuously for 22 days, and 10 normal rats were taken as normal control group. The kidney coefficient, serum calcium, phosphorus, parathyroid hormone (PTH), creatinine (creatinine), urea nitrogen (urea nitrogen) and pathological changes of kidney were detected in each group. Results: compared with the normal control group, the rats in the model group showed signs of chronic renal failure, renal coefficient and the contents of phosphoric acid PTH, creatinine, urea nitrogen increased, calcium content decreased P 0.01, and the renal sections showed obvious pathological characteristics. Compared with the model group, the chronic renal failure signs of rats in lanthanum carbonate group, calcium carbonate group and lanthanum hydroxide group were improved, and the renal coefficient (except lanthanum hydroxide high dose group) and phosphorus (except calcium carbonate group) and phosphorus (except lanthanum hydroxide low dose group) were improved. The contents of urea nitrogen in calcium carbonate group and calcium phosphate product (only calcium carbonate group) increased significantly (P 0.05 or P 0.01), except for lanthanum hydroxide low dose group and calcium carbonate group. The pathological features of renal sections were improved. Conclusion: lanthanum hydroxide can improve renal function and decrease serum phosphorus content in rats with chronic renal failure hyperphosphatemia.
【作者单位】：内蒙古医科大学药学院;内蒙古包头市第四医院药剂科;
【基金】：国家自然科学基金资助项目(No.81260650,81560685) 内蒙古自然科学基金资助项目(No.2014BS0805) 内蒙古医科大学科技百万工程基金项目(No.NYKJBW004)
【分类号】：R692.5

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