多房囊性肾细胞癌18例临床病理分析

发布时间：2018-05-07 10:18

本文选题：肾肿瘤 + 多房囊性肾细胞癌　；参考：《临床与实验病理学杂志》2015年06期

【摘要】：目的探讨多房囊性肾细胞癌(multilocular cystic renal cell carcinoma,MCRCC)的临床病理学特征、诊断及鉴别诊断。方法回顾性分析18例MCRCC的临床病理学及免疫表型特征,并复习相关文献。结果 18例中男性12例,女性6例,年龄26~68岁(平均55.6岁)。影像学检查均示多囊性占位,边界清楚。眼观:肿瘤切面见大小不等的多房囊腔,内含浆液性或血性液体。镜检:肿瘤囊内壁被覆单层透明细胞、复层上皮或上皮缺如,囊内成分大部分流失,纤维性囊壁或囊腔间隔中见灶状透明细胞,呈Ⅰ级细胞核,其为形态学诊断线索。免疫表型:透明细胞CD10、vimentin、EMA均阳性,Ki-67增殖指数低。18例患者平均随访43个月,均无复发或转移,预后良好。结论 MCRCC是一种罕见的肾细胞癌组织学亚型,预后良好,需与肾透明细胞癌囊性变及良性肾囊性病变相鉴别。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of multilocular cystic renal cell carcinoma. Methods the clinicopathological and immunophenotypic features of 18 cases of MCRCC were analyzed retrospectively. Results there were 12 males and 6 females aged 2668 years (mean 55.6 years). Imaging examination showed multiple cystic mass with clear boundary. Eye view: multiple cystic cavities of varying sizes are seen on the tumor section, containing serous or bloody fluid. Microscopic examination: clear cells were coated on the inner wall of the tumor, the epithelium or epithelium were absent, most of the components of the capsule were lost, and focal clear cells were found in the fibrous cystic wall or the septum of the capsule, showing grade I nucleus, which was the clue of morphological diagnosis. Immunophenotypes: the proliferative index of Ki-67 was lower in 18 patients with CD10V EMA positive. 18 patients were followed up for an average of 43 months. There was no recurrence or metastasis, and the prognosis was good. Conclusion MCRCC is a rare histologic subtype of renal cell carcinoma and has a good prognosis. It should be distinguished from cystic degeneration and benign renal cysts of renal clear cell carcinoma.
【作者单位】：新疆自治区人民医院病理科;
【分类号】：R737.11

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