评价对比剂肾病患者继发终末期肾脏病的风险模型及应用性研究

发布时间：2018-05-16 15:49

本文选题：对比剂肾病 + 终末期肾脏病　；参考：《中国介入影像与治疗学》2017年11期

【摘要】：目的搜集与对比剂肾病(CIN)相关的临床指标,构建评判该患者继发终末期肾脏病(ESRD)的风险性模型,并验证其应用性。方法连续性纳入CIN患者为研究队列,分析研究对象初始入院时的各项临床资料及实验室检查结果,并对其进行为期18个月的随访以确认预后,依据随访结果,进行远期风险性预测和相关危重度评判分析。结果本次研究纳入215例CIN患者,14例失访,19例随访期内进展至ESRD。Cox回归分析显示,近期重复接受造影、高MRS量表评分、高尿肾损伤分子-1(uKIM-1)含量、高尿微量蛋白(umAlb)含量、高尿中性粒细胞明胶酶相关脂质运载蛋白(uNGAL)含量为CIN患者发病18个月内继发ESRD的独立危险因素。以umAlb=36.80ng/ml、uNGAL=128.21ng/ml、uKIM-1=137.56pg/ml为临界值预测CIN患者进展至ESRD的ROC曲线下面积分别为0.746、0.756、0.768。结论本研究建立CIN患者继发ESRD的风险预测模型,并对相关危险因素进行了量化,进一步完善了CIN的诊疗体系。
[Abstract]:Objective to collect the clinical indexes associated with contrast-agent Nephropathy (CINs), and to establish a risk model for evaluating ESRD in patients with secondary end-stage renal disease (ESRD), and to verify its application. Methods the clinical data and laboratory results of the patients with CIN were analyzed and followed up for 18 months to confirm the prognosis, according to the results of follow-up. Carries on the long-term risk forecast and the correlation critical degree judgment analysis. Results during the follow-up period, 14 patients with CIN were included in this study. The results of ESRD.Cox regression analysis showed that in the near future repeated angiography, high MRS scale score, high urine renal injury molecule-1 UKIM-1 content, high urinary trace protein content, and high urinary microalbumen content were found in this study. High urinary neutrophil gelatinase-associated lipid carrier protein (CIN) is an independent risk factor for secondary ESRD in patients with CIN within 18 months. The critical value of umAlbn 36.80ng / ml NGALA 128.21ng / ml is to predict the area under the ROC curve of CIN patients from 0.746ng-1 to 137.56pg / ml, respectively. Conclusion this study established a risk prediction model for secondary ESRD in patients with CIN and quantified the related risk factors and further improved the diagnosis and treatment system of CIN.
【作者单位】：福建医科大学附属宁德市医院介入科;
【分类号】：R692

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