环孢素在肾病综合征患者中的用药状况分析

发布时间：2018-05-18 06:41

本文选题：环孢素 + 肾病综合征　；参考：《中国临床药理学杂志》2017年23期

【摘要】：目的分析环孢素在我院肾病综合征患者中的用药情况及特点。方法收集2014年北京大学第一医院全年使用环孢素治疗肾病综合征的住院患者病例,提取患者的基本情况、治疗药物监测情况、合并用药情况、疗效及药物不良反应信息,用SPSS 22.0软件进行统计分析。结果共纳入68例患者,住院次数为76次,进行环孢素谷浓度测定132例次。患者肾病综合征治疗的有效率为36.84%,环孢素药物不良反应发生率为4.41%。环孢素谷浓度在50~100ng·m L~(-1)时,有效率最高。47.06%的患者住院期间合并使用地尔硫治疗。合用地尔硫的患者与不合用患者的平均谷浓度、达到50~100 ng·m L~(-1)谷浓度范围所需时间、环孢素平均剂量及有效率比较,差异均无统计学意义(均P0.05)。结论本院肾病综合征患者环孢素的使用基本合理,但在治疗药物监测方面还存在一些不足。
[Abstract]:Objective to analyze the drug use of cyclosporine in patients with nephrotic syndrome in our hospital. Methods the inpatients who were treated with cyclosporine for nephrotic syndrome in the first Hospital of Peking University in 2014 were collected. The basic information of the patients, the monitoring of treatment drugs, the combined use of drugs, the curative effect and the adverse drug reactions were collected. Statistical analysis was carried out with SPSS 22. 0 software. Results Sixty-eight patients were included, 76 times of hospitalization and 132 times of determination of cyclosporine valley concentration. The effective rate of treatment of nephrotic syndrome was 36.84 and the incidence of adverse drug reaction of cyclosporine was 4.41. When the concentration of cyclosporine was at 50~100ng m / L ~ (-1), the highest effective rate was. 47.06% patients were treated with diltiazem during hospitalization. There was no significant difference in the mean valley concentration between the patients with and without diltiazem, the mean dose and the effective rate of cyclosporine (P 0.05). Conclusion the use of cyclosporine in patients with nephrotic syndrome in our hospital is reasonable, but there are some deficiencies in drug monitoring.
【作者单位】：北京大学第一医院药剂科;北京大学药学院药事管理与临床药学系;
【分类号】：R692

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