左卡尼汀对老年终末期肾病维持性血液透析患者炎症及营养状况的影响

发布时间：2018-05-26 11:23

本文选题：左卡尼汀 + 维持性血液透析　；参考：《中国老年学杂志》2017年19期

【摘要】：目的探析左卡尼汀(L-CN)对接受维持性血液透析(MHD)治疗的终末期肾病(ESRD)老年患者的微炎症及贫血、营养不良状态的影响。方法 MHD治疗的54例ESRD老年患者随机分成观察组(L-CN治疗)和对照组(无L-CN治疗),分别为26和28例。比较两组基线资料、炎性因子、营养及贫血改善指标的表达水平。结果治疗前两组各炎性指标,包括血清白细胞介素(IL)-6,IL-8,超敏C反应蛋白(hs-CRP),肿瘤坏死因子(TNF)-α与脂蛋白[La(a)]水平无显著差异(P0.05);治疗后,对照组各炎性指标水平与治疗前无显著差异(P0.05),而观察组各炎性指标水平较对照组与治疗前均明显降低(P0.05)。治疗前两组营养及贫血指标,包括血浆白蛋白(Alb)、血细胞比容(Hct)、血红蛋白(Hb)、转铁蛋白(TRF)、血浆总蛋白(TP)及前白蛋白(PAB)的表达水平无显著差异(P0.05);治疗后,对照组各指标较治疗前无显著差异(P0.05),而观察组各指标较对照组及治疗前均显著升高(P0.05)。结论 L-CN治疗不但可以显著改善MHD老年ESRD患者的微炎症反应,还可以纠正肾性贫血和营养不良的状态。
[Abstract]:Objective to investigate the effects of L-CNL on microinflammation, anemia and malnutrition in elderly patients with end-stage renal disease (ESRD) treated with maintenance hemodialysis (MHD). Methods 54 elderly patients with ESRD treated with MHD were randomly divided into two groups: observation group (n = 26) and control group (n = 28). The expression of baseline data, inflammatory factors, nutrition and anemia were compared between the two groups. Results there was no significant difference in the levels of serum IL-8, hs-CRP, TNF- 伪 and lipoprotein between the two groups before treatment, including IL-8, hs-CRP, TNF- 伪 and lipoprotein (Lahua-), after treatment, there was no significant difference between the two groups (P 0.05). There was no significant difference in the levels of inflammatory indexes between the control group and the control group before treatment (P 0.05), but the levels of each inflammatory index in the observation group were significantly lower than those in the control group and before treatment (P 0.05). Before treatment, there was no significant difference in the levels of nutritional and anemia indexes between the two groups, including the expression of plasma albumin Albbumin, HCT, HBC, TRFT, TPTP and PAB.After treatment, there was no significant difference between the two groups (P 0.05), and after treatment, there was no significant difference between the two groups in the expression levels of TRFF, TPTP and PAB.After the treatment, there was no significant difference in the expression levels between the two groups. There was no significant difference in the indexes of the control group compared with that before treatment, but the indexes of the observation group were significantly higher than those of the control group and before treatment. Conclusion the treatment of L-CN can not only improve the microinflammation in MHD elderly patients with ESRD, but also correct renal anemia and malnutrition.
【作者单位】：海南省农垦总医院肾内科;
【基金】：海南省科学技术厅应用技术研发与示范推广专项项目(No.ZDXM2015085)
【分类号】：R692.5

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