IgG4升高的肾病:IgG4相关性肾病与特发性膜性肾病的研究进展

发布时间：2018-05-27 20:03

本文选题：肾病 + 免疫球蛋白G　；参考：《中国全科医学》2016年36期

【摘要】：IgG4相关性疾病是以血清IgG4升高、组织IgG4浆细胞浸润以及纤维性病变为特征的多系统疾病,可累及胰腺、肾脏、唾液腺等多种器官,累及肾脏时称为IgG4相关性肾病,主要表现为IgG4相关性肾小管间质性肾炎,累及肾小球时以膜性肾病多见。而特发性膜性肾病的免疫复合物沉积也以IgG4为主,在临床上区分IgG4相关性疾病继发的膜性肾病与特发性膜性肾病非常重要。本文从发病机制、临床表现、诊断及治疗等方面探讨IgG4相关性肾病与特发性膜性肾病的区别,为临床的诊治提供一定的理论基础。
[Abstract]:IgG4 associated disease is a multisystem disease characterized by the elevation of serum IgG4, the infiltration of IgG4 plasma cells and fibrous lesions. It can involve many organs, such as pancreas, kidney, salivary gland and so on. When the kidney is involved, it is called IgG4 associated nephropathy. IgG4 associated tubulointerstitial glomerulonephritis was the main manifestation, and membranous nephropathy was more common in glomeruli. The immune complex deposition of idiopathic membranous nephropathy is also dominated by IgG4. It is very important to distinguish membranous nephropathy from idiopathic membranous nephropathy in clinic. This paper discusses the differences between IgG4 associated nephropathy and idiopathic membranous nephropathy from the aspects of pathogenesis, clinical manifestation, diagnosis and treatment, and provides a theoretical basis for clinical diagnosis and treatment.
【作者单位】：第二军医大学附属长征医院肾内科;
【分类号】：R692

【相似文献】