肾炎康复片辅助标准激素治疗气阴两虚证肾病综合征80例临床观察

发布时间：2018-05-31 17:27

本文选题：肾炎康复片 + 标准激素　；参考：《中国实验方剂学杂志》2015年21期

【摘要】：目的:探讨肾炎康复片辅助标准激素治疗气阴两虚型肾病综合征(NS)的临床疗效以及对血小板数量(PLT)和血浆垂体腺苷酸环化酶激活肽(PACAP)的影响。方法:152例NS患者参照随机按分层随机法分为治疗组80例和对照组72例;两组患者均采取常规支持治疗和对症处理;对照组采用泼尼松,首始剂量l mg·kg-1·d-1,最大剂量不超过60 mg·d-1,连续口服8~12周,再以每2周减少原使用量的10%内服,最后以10 mg·d-1的剂量维持治疗,根据具体情况维持6~12个月,同时给予对症治疗。治疗组在对照组治疗的基础上加服肾炎康复片,5片/次,3次/d,两组均连续治疗12个月。检测治疗前后两组患者的24 h尿蛋白定量,血清白蛋白(ALB),总胆固醇(TC)和甘油三脂(TG)水平;监测两组肝功能,记录治疗过程中不良反应发生率;比较两组治疗前后中医(TCM)单项症状评分;检测两组治疗前后PLT和血浆PACAP水平。结果:治疗组临床总有效率为97.5%,对照组为79.17%,治疗组明显优于对照组(P0.01);治疗组治疗后24 h尿蛋白定量,TG和TC水平明显低于对照组,血清ALB水平显著高于对照组(P0.01);治疗后治疗组患者的向心性肥胖和总体不良反应发生率明显少于对照组(P0.05);治疗组治疗后TCM各单项指标评分均明显低于对照组,比较差异均有统计学意义(P0.01);治疗组治疗后PLT数量明显低于对照组,血浆PACAP水平显著高于对照组,比较差异均有统计学意义(P0.01)。结论:肾炎康复片辅助标准激素治疗气阴两虚型NS能提高临床疗效,减少不良反应发生,降低患者血小板数量和升高血浆PACAP水平。
[Abstract]:Objective: to investigate the clinical efficacy of nephritis rehabilitation tablets in the treatment of Nephrotic Syndrome with deficiency of Qi and Yin (NSN) and its effects on platelet count and plasma adenylate cyclase activating peptide (PACAP). Methods 152 cases of NS were randomly divided into treatment group (n = 80) and control group (n = 72). The first dose was 1 mg kg-1 d -1 and the maximum dose was not more than 60 mg d -1. The first dose was taken orally for 812 weeks, then 10% of the original dosage was reduced every 2 weeks. Finally, the dosage of 10 mg d -1 was maintained for 6 ~ 12 months according to the specific conditions, and the symptomatic treatment was given at the same time. On the basis of the treatment in the control group, the treatment group was given 5 tablets of nephritis rehabilitation tablet / 3 times / d, and both groups were treated continuously for 12 months. Before and after treatment, the levels of 24 h urine protein, serum albumin, total cholesterol (TCC) and triglyceride (TG) were measured, liver function was monitored and the incidence of adverse reactions was recorded. The single symptom score of TCM was compared before and after treatment, and the levels of PLT and plasma PACAP were measured before and after treatment. Results: the total clinical effective rate of the treatment group was 97.5 and that of the control group was 79.17, which was obviously superior to that of the control group (P 0.01), and the levels of TG and TC in the treatment group 24 h after treatment were significantly lower than those in the control group. The level of serum ALB was significantly higher than that of control group (P 0.01), the incidence of cardiac obesity and total adverse reactions in the treatment group was significantly lower than that in the control group (P 0.05), and the score of each single index of TCM in the treatment group was significantly lower than that in the control group. The amount of PLT in the treatment group was significantly lower than that in the control group, and the plasma PACAP level was significantly higher than that in the control group. Conclusion: the treatment of NS with deficiency of Qi and Yin by the auxiliary standard hormone of nephritis rehabilitation tablet can improve the clinical efficacy, reduce the occurrence of adverse reactions, reduce the platelet count and increase the plasma PACAP level.
【作者单位】：淄博市中心医院;山东省立医院;
【基金】：淄博市科技局青年基金项目(2013A100541)
【分类号】：R692

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