肾移植术后的高钙血症

发布时间：2018-06-09 14:41

本文选题：肾移植 + 高钙血症　；参考：《肾脏病与透析肾移植杂志》2017年01期

【摘要】：随着肾功能的减退,慢性肾脏病(CKD)患者不仅出现血钙、血磷水平变化和继发性甲状旁腺功能亢进,还将引发骨代谢异常和血管及软组织钙化,称为慢性肾脏病矿物质和骨异常(CKD-MBD)。肾移植术后,大部分受者CKD-MBD的症状得到极大改善,但部分受者会出现高钙血症。高钙血症发生率的报道差异很大。肾移植术后1年内高钙血症发生率为15%~30%,1年后发生率为5%~10%。影响因素包括术前透析时间和术后持续的甲状旁腺功能亢进等。随着肾功能的恢复,部分受者术后早期的高钙血症可自行缓解。持续严重的高钙血症可能加重异位钙化,增加肾脏损害、心血管疾病及死亡风险,故需要积极寻找原因,并予治疗和纠正,这对提高肾移植受者的生活质量和远期预后具有重要意义。
[Abstract]:With the decline of renal function, the changes of serum calcium and phosphorus levels and secondary hyperparathyroidism in patients with chronic kidney disease (CKDD) will lead to abnormal bone metabolism and calcification of blood vessels and soft tissue. After renal transplantation, the symptoms of CKD-MBD were greatly improved in most recipients, but hypercalcemia occurred in some recipients. The reported incidence of hypercalcemia varies widely. The incidence of hypercalcemia in one year after renal transplantation was 15 and 30, and that after 1 year was 510. Influencing factors include preoperative dialysis time and postoperative hyperparathyroidism. With the recovery of renal function, the early hypercalcemia in some recipients can be relieved by themselves. Persistent and severe hypercalcemia may exacerbate ectopic calcification, increase the risk of kidney damage, cardiovascular disease and death, and therefore need to be actively explored, treated and corrected. This is of great significance to improve the quality of life and long-term prognosis of renal transplant recipients.
【作者单位】：第二军医大学金陵医院(南京军区南京总医院)肾脏科;第二军医大学金陵医院(南京军区南京总医院)肾脏科国家肾脏疾病临床医学研究中心全军肾脏病研究所;
【分类号】：R699.2

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