慢性肾脏疾病与高尿酸血症的相关性研究

发布时间：2018-06-13 16:09

本文选题：慢性肾脏疾病 + 肾小球滤过率　；参考：《辽宁医学院学报》2014年05期

【摘要】：目的探究慢性肾脏疾病(chronic kidney disease,CKD)与高尿酸血症(hyperuricemia)的关联性。方法选取弋矶山医院肾内科198例入院患者作为研究对象,开展横断面研究。进行肾小球滤过率(GFR)的测定(GFR60 mL/min/1.73 m2定义为CKD),并收集相关危险因素资料。选用多变量二分类Logistic回归分析来研究UA与CKD之间的相关性。结果多变量二分类Logistic回归分析显示,随着尿酸水平的升高,CKD的患病风险呈上升趋势(趋势检验P0.05)。在调整了年龄,体重,体重指数(body mass index,BMI),血压、空腹血糖,总胆固醇(total cholesterol,TC),甘油三酯(triglyceride,TG)等影响因素后,与对照UA组相比,第2组患CKD的相对危险度(OR)为2.54(95%CI:1.51~4.83),第3组患CKD的OR值为4.65(95%CI:2.73~6.21),第4组患CKD的OR值为11.68(95%CI:6.41~15.92)。结论 CKD与高尿酸血症之间存在相关性,随着UA水平的升高,CKD的患病风险也逐渐升高。
[Abstract]:Objective to investigate the relationship between chronic kidney disease (CKD) and hyperuricemia. Methods A cross-sectional study was carried out in 198 patients in Department of Renal Medicine of Gigi Mountain Hospital. The glomerular filtration rate (GFR) was measured. GFR 60 mL / min / 1.73 m2 was defined as CKDN and relevant risk factors were collected. Multivariate binary logistic regression analysis was used to study the correlation between UA and CKD. Results multivariate logistic regression analysis showed that the risk of CKD increased with the increase of uric acid level (trend test, P 0.05). After adjusting for age, body mass index (BMI), blood pressure, fasting blood glucose, total cholesterol TC, triglyceride TGs and so on, compared with the control UA group, The relative risk of CKD in group 2 was 2.54 ~ 955.CI: 1.51 ~ 4.83%, OR value of CKD in group 3 was 4.65 ~ 95% CI: 2.73 ~ 6.21, OR value of CKD in group 4 was 11.68 ~ 95 ~ (95) CI: 6.4115.92. Conclusion there is a correlation between CKD and hyperuricemia, and the risk of CKD increases with the increase of UA level.
【作者单位】：皖南医学院弋矶山医院肾内科;
【分类号】：R692

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