深圳地区692例IgA肾病临床病理分析

发布时间：2018-06-15 16:32

本文选题：IgA肾病 + 深圳　；参考：《实用医学杂志》2017年12期

【摘要】：目的:探讨深圳地区IgA肾病患者的临床病理特征。方法:回顾性分析692例经肾活检确诊为IgA肾病患者的临床病理资料。结果 :深圳地区的IgA肾病患者以青年居多。各年龄组之间舒张压、24 h尿蛋白定量、镜下血尿、白细胞、血胆固醇、血白蛋白、血IgA、血C_3,血糖水平差异无统计学意义(P0.05)。老年组的收缩压、血肌酐、肾小球滤过率(eGFR)、血尿酸、血IgG与青、中年组比较存在差异(P0.05)。青少年组及老年组感染比率较中年组高(P0.05)。病理方面,不同年龄组在肾小管间质积分、肾小动脉积分及总积分差异有统计学意义(P0.05),肾小球积分差异无统计学意义(P0.05)。结论:深圳地区IgA肾病属于常见的肾小球疾病之一。以青少年发病为主,老年IgA肾病患者肾小管间质与血管的病变重于青中年组;感染在老年患者比较常见。
[Abstract]:Objective: to investigate the clinicopathological features of IgA nephropathy in Shenzhen area. Methods: the clinical and pathological data of 692 patients with IgA nephropathy diagnosed by renal biopsy were analyzed retrospectively. Results: the majority of patients with IgA nephropathy in Shenzhen area were young people. There was no significant difference in blood urine, white blood cell, serum cholesterol, serum albumin, serum IgA, blood C3 and blood glucose level between different age groups (P 0.05). The systolic blood pressure, serum creatinine, glomerular filtration rate (GFR), serum uric acid, serum IgG in the aged group were significantly different from those in the young and middle age group (P 0.05). The infection rate in the young group and the elderly group was higher than that in the middle age group (P 0.05). Pathologically, there were significant differences in tubulointerstitial integral, renal arteriole score and total integral between different age groups (P 0.05), but no significant difference in glomerular integral (P 0.05). Conclusion: IgA nephropathy is one of the common glomerular diseases in Shenzhen. The renal tubulointerstitial and vascular lesions were more serious in elderly patients with IgA nephropathy than in young and middle aged patients, and infection was more common in elderly patients.
【作者单位】：北京大学深圳医院肾内科;北京大学深圳医院病理科;
【基金】：深圳市卫生计生系统科研项目(编号:201401031)
【分类号】：R692.31

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