狼疮性肾炎患者医院感染临床特点与病理的关系

发布时间：2018-06-17 20:22

本文选题：狼疮性肾炎 + 医院感染　；参考：《中华医院感染学杂志》2015年02期

【摘要】：目的探讨狼疮性肾炎(LN)并发医院感染临床特点及与病理的关系。方法回顾性分析2009年11月-2013年11月医院的60例LN住院患者的临床资料,对并发医院感染的临床特点及其与病理之间的关系进行分析。结果 60例LN患者中发生医院感染28例,感染率46.67%;主要感染部位分别为肺部、泌尿道、消化道及皮肤;感染病原菌以细菌为主,革兰阳性菌占50.00%、革兰阴性菌占28.57%,真菌次之;急性肾炎综合征型、急进型肾炎综合征型、肾病综合征型、肾炎-肾病综合征型感染率分别为80.00%、75.00%、56.25%、66.67%,均显著高于尿检异常型与终末期尿毒症型(均为10.00%),差异有统计学意义(P0.01);随着病理类型的提高,感染率也随之而增大;两种方法联合治疗患者感染率显著高于单一方法治疗患者(P0.05);感染组与非感染组在住院时间、血红蛋白、24h尿蛋白、血浆白蛋白、SLEDAI评分、补体C3及肌酐方面的差异均具有统计学意义(P0.05)。结论 LN并发医院感染与临床、病理类型,长期大量应用激素、免疫抑制剂以及长时间住院等密切相关。
[Abstract]:Objective to investigate the clinical features of nosocomial infection in patients with lupus nephritis (LN) and its relationship with pathology. Methods the clinical data of 60 patients with LN in hospital from November 2009 to November 2013 were analyzed retrospectively. The clinical characteristics of nosocomial infection and its relationship with pathology were analyzed. Results Nosocomial infection occurred in 28 out of 60 LN patients with infection rate of 46.67.The main sites of infection were lung, urinary tract, digestive tract and skin, the main pathogenic bacteria were bacteria, Gram-positive bacteria accounted for 50.00g positive bacteria, Gram-negative bacteria accounted for 28.57m, fungi took second place. Acute nephritis syndrome, nephrotic syndrome, The infection rates of nephritis and nephrotic syndrome type were 80.000 and 56.250.67, respectively, which were significantly higher than those of urine abnormal type and end-stage uremia type (10.00%, P 0.01), and the infection rate also increased with the increase of pathological type. The infection rate of the two methods combined treatment was significantly higher than that of the single treatment group (P 0.05N), the duration of hospitalization, hemoglobin 24 hours urine protein, plasma albumin and SLEDAI score in the infection group and the non-infection group were significantly higher than that in the single treatment group. The differences of complement C 3 and creatinine were statistically significant (P 0.05). Conclusion Nosocomial infection associated with LN is closely related to clinical, pathological types, long-term use of hormones, immunosuppressive agents and long hospitalization.
【作者单位】：咸宁市中心医院儿科;
【基金】：湖北省卫生厅科研基金资助项目(Z201311)
【分类号】：R593.242

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