信号转导和转录激活因子3和细胞周期蛋白D1在膀胱尿路上皮癌组织表达及意义

发布时间：2018-07-01 08:27

本文选题：膀胱尿路上皮癌 + 信号转导和转录激活因子(STAT)　；参考：《中国老年学杂志》2016年16期

【摘要】：目的应用免疫组化方法检测膀胱尿路上皮癌中信号转导和转录激活因子(STAT)3和细胞周期蛋白(Cyclin)D1的表达,分析其关联性及在不同临床病理特征中的价值。方法观察组选择56例膀胱尿路上皮癌患者的临床资料及术后蜡块组织,对照组选择26例正常膀胱黏膜组织。应用免疫组化SP法检测两组中STAT3和Cyclin D1的表达。结果两组中STAT3和Cyclin D1表达的阳性率差异有统计学意义。观察组中STAT3和Cyclin D1表达的阳性率均与肿瘤最大径、浸润程度和病变级别相关。相关分析显示观察组中STAT3和Cyclin D1的表达呈正相关性。结论膀胱尿路上皮癌术后组织中STAT3和Cyclin D1高表达,且二者具有正向协同作用。二者异常表达均是肿瘤形成和进展的促进因素。
[Abstract]:Objective to detect the expression of signal transduction and transcription activator (stat) 3 and cyclin D1 (Cyclin D1) in bladder urothelial carcinoma (UEC) by immunohistochemical method, and to analyze the relationship between STAT3 and cyclin D1 and their value in different clinicopathological features. Methods the clinical data and postoperative wax tissue of 56 cases of bladder urothelial carcinoma and 26 cases of normal bladder mucosa were selected in the observation group and the control group respectively. The expressions of STAT3 and Cyclin D1 in the two groups were detected by immunohistochemical SP method. Results the positive rates of STAT3 and Cyclin D1 were significantly different between the two groups. The positive rates of STAT3 and Cyclin D1 expression were correlated with the maximum diameter of tumor, the degree of invasion and the grade of lesion. Correlation analysis showed positive correlation between STAT3 and Cyclin D1 expression in observation group. Conclusion STAT3 and Cyclin D1 are highly expressed in bladder urothelial carcinoma after operation, and they have positive synergistic effect. The abnormal expression of both of them is the promoting factor of tumor formation and progression.
【作者单位】：锦州医科大学附属第一医院;
【分类号】：R737.14

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