逐利口服液治疗肾病综合征的临床疗效观察

发布时间：2018-07-05 10:02

本文选题：肾病综合征 + 逐利口服液　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:观察逐利口服液在治疗阴虚火旺型肾病综合症患者中对激素副作用及相关化验中指标的影响,探索逐利口服液在治疗肾病综合症时所发挥的作用。通过观察和评价逐利口服液联合激素治疗原发性肾病综合征的临床疗效,探讨逐利口服液发挥疗效的具体作用机理及临床实际应用中的价值,为进一步发展用中西医结合方法治疗原发性肾病综合症提供新的治疗思路。方法:选取同时满足中西医诊断纳入标准的患者60例,随机分为对照组和治疗组,每组各30例。对照组和治疗组都给予常规激素治疗(强的松1mg kg/d,晨起顿服),治疗组加服中药逐利口服液(日一剂,水煎分服,每日2次)治疗,其它的基础性治疗保持一致。疗程为8周,必要时可根据激素用量情况延长至12周,观察治疗前后治疗组与对照组的中医证候积分及肾功,24小时尿蛋白定量,皮质醇,凝血系列,血脂等实验室指标的变化,归纳总结治疗前后数据,应用统计学方法进行分并探讨。结果:1.临床疗效:治疗组和对照组的总有效率分别为93.3%,86.7%,数据结果客观显示治疗组的临床疗效明显高于对照组的临床疗效。2.中医症状疗效:经足量激素治疗后两组中医症状积分都有显著升高,但加用逐利口服液的治疗组积分升高程度轻于对照组,治疗组具有改善中医阴虚火旺证候的临床疗效,五心烦热、口燥咽干、失眠多梦等表现在治疗组中的变现明显优于对照组。3.治疗组和对照组中的相关实验室化验指标,如尿蛋白,血清白蛋白,血脂及血清Cor等化验结果均得到明显改善,治疗组化验指标变化更明显。结论:1.在常规激素治疗基础上,治疗组加用逐利口服液治疗,研究结果表明逐利口服液与激素治疗具有较好的协同作用,能显著提高激素治疗的临床效果,减轻不良反应,值得更进一步的临床分析及研究。2.逐利口服液对原发性肾病综合征(阴虚火旺型)患者有显著的临床疗效,该方能够显著的降低激素发挥治疗作用过程中所带来的副作用,同时降低尿蛋白水平和提高血清白蛋白水平,改善肾病综合征患者血脂情况,有效的改善阴虚火旺型患者的五心烦热、口燥咽干、失眠多梦、舌红少苔等症候表现。3.逐利口服液的滋阴降火作用可积极用于治疗原发性肾病综合征(阴虚火旺型)的患者,必要时随症加减。
[Abstract]:Objective: to observe the effect of Zhuli oral liquid on the side effects of hormone and related indexes in the treatment of nephrotic syndrome with yin deficiency and fire and to explore the role of Zhuli oral liquid in the treatment of nephrotic syndrome. By observing and evaluating the clinical effect of Zhuli oral liquid combined with hormone in treating primary nephrotic syndrome, the mechanism and value of Zhuli oral liquid in treating primary nephrotic syndrome were discussed. For the further development of integrated traditional Chinese and western medicine treatment of primary nephrotic syndrome to provide a new treatment ideas. Methods: 60 patients who met the criteria of diagnosis and treatment were randomly divided into control group and treatment group with 30 cases in each group. The control group and the treatment group were given routine hormone therapy (prednisone 1mg / kg / d, morning meal), the treatment group was treated with traditional Chinese medicine Zhuli oral liquid (one dose per day, two times a day), and the other basic treatments remained the same. The course of treatment was 8 weeks, which could be extended to 12 weeks according to the dosage of hormone. The changes of TCM syndromes integral and 24 hour urinary protein quantification, cortisol, coagulation series, blood lipid and other laboratory indexes were observed before and after treatment in the treatment group and the control group. The data before and after treatment were summarized and analyzed by statistical method. The result is 1: 1. Clinical efficacy: the total effective rate of the treatment group and the control group were 93.3or 86.7, respectively. The data showed that the clinical efficacy of the treatment group was significantly higher than that of the control group. The curative effect of TCM symptom: after sufficient hormone treatment, the scores of TCM symptoms in both groups were significantly increased, but the scores in the treatment group treated with Zhuli oral liquid were slightly higher than those in the control group, and the treatment group had the clinical effect of improving the syndrome of yin deficiency and fire and flourishing. Five upset heat, dry mouth dryness, insomnia and many dreams in the treatment group was significantly better than the control group. 3. The results of laboratory tests, such as urine protein, serum albumin, serum lipids and serum Cor, were significantly improved in the treatment group and the control group, especially in the treatment group. Conclusion 1. On the basis of routine hormone therapy, the treatment group was treated with Zhuli oral liquid. The results showed that Zhuli oral liquid had good synergistic effect with hormone therapy, which could significantly improve the clinical effect of hormone therapy and alleviate adverse reactions. Worthy of further clinical analysis and research. Zhuli oral liquid has a significant clinical effect on patients with primary nephrotic syndrome (Yin deficiency and fire flourishing type). It can significantly reduce the side effects of hormone in the course of treatment. At the same time, urinary protein level and serum albumin level were decreased, blood lipid was improved in patients with nephrotic syndrome, the symptoms of five upset heat, dry throat, insomnia and dream, tongue red and little fur were effectively improved. 3. Zhuli oral liquid can be used to treat the patients with primary nephrotic syndrome (Yin deficiency and fire flourishing type), if necessary, it can be added or subtracted with the syndrome.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R692

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