素食饮食对慢性透析患者营养状态和心血管风险的影响

发布时间：2018-07-15 16:12

【摘要】：目的研究素食饮食对慢性透析患者营养状态和心血管风险的影响。方法采用病例对照研究,共63例受试者,包括素食组(21例)和非素食组(42例),所有研究对象均接受肱踝脉搏传导速度(ba PWV)检测。血标本于纳入研究的第1天早上空腹采集,包括血尿素氮、血肌酐、血常规、血清白蛋白、超敏C反应蛋白、全段甲状旁腺素、尿酸、维生素B12、同型半胱氨酸、标准蛋白代谢率、血25(OH)D、血脂。详细记录24 h的饮食情况。结果与非素食组相比,素食组体重、体质指数、血磷、尿素氮、血肌酐、维生素D、尿酸、白蛋白水平及标准蛋白排泄率显著降低(P0.05),ba PWV显著升高(P0.05),校正年龄、白蛋白、透析前收缩压、透析持续时间后,素食饮食仍然是影响ba PWV的独立危险因素。结论慢性透析患者若长期素食饮食可能会导致亚临床蛋白质营养不良和维生素D缺乏,这种影响会抵消其对心血管系统的保护作用。
[Abstract]:Objective to study the effects of vegetarian diet on nutritional status and cardiovascular risk in chronic dialysis patients. Methods A case-control study was conducted in 63 subjects, including vegetarian group (21 cases) and non-vegetarian group (42 cases). All subjects were tested for brachial ankle pulse conduction velocity (PWV). Blood samples were collected on an empty stomach on the first day of the study, including blood urea nitrogen, serum creatinine, blood routine, serum albumin, hypersensitive C-reactive protein, whole segment parathyroid hormone, uric acid, vitamin B12, homocysteine. Standard protein metabolic rate, blood 25 (OH) D, blood lipids. The diet for 24 hours was recorded in detail. Results compared with the control group, the body weight, body mass index, blood phosphorus, urea nitrogen, serum creatinine, vitamin D, uric acid, albumin level and standard protein excretion rate in the vegetarian group were significantly decreased (P0.05). Systolic blood pressure before dialysis and duration after dialysis, vegetarian diet is still an independent risk factor for ba PWV. Conclusion Long-term vegetarian diet may lead to subclinical protein malnutrition and vitamin D deficiency in chronic dialysis patients, which may counteract its protective effect on cardiovascular system.
【作者单位】：南方医科大学中医药学院;
【基金】：国家自然科学基金资助项目(编号:81573729,81373808)
【分类号】：R692.5

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