等离子双极电切技术在前列腺增生患者中的应用研究
发布时间：2018-07-22 10:25
【摘要】：第一部分 国产与进口等离子双极电切环对犬前列腺组织病理学影响的对照研究目的：对比研究国产与进口等离子双极电切环对犬前列腺组织病理学影响。方法：18只成年雄性杂种犬随机分为2组：进口电切环组(9只)、国产电切环组(9只)。于术后0(术后立即)、1、6周分别取各组动物处死,获取前列腺标本,光镜下观察前列腺组织病理学改变并测量创面凝固层厚度。结果：术后0、1周,进口电切环组和国产电切环组前列腺组织创面的凝固层厚度分别为(235.45±25.37)μm、(110.87±20.23)μm和(238.12±32.47)μm、(112.64±18.76)μm,术后0、1周两组相比,差异无统计学意义(P0.05)。术后6周,进口电切环组和国产电切环组前列腺组织创面凝固层完全脱落,创面均被覆再生的尿路上皮。术后0、1、6周,进口电切环组和国产电切环组前列腺组织均有不同程度的炎症反应,凝固层下部分腺腔扩张,上皮破坏。结论：使用进口电切环和国产电切环对犬前列腺组织创面的病理学影响基本相似。第二部分前列腺等离子双极电切技术在治疗大体积前列腺增生(80g)中的应用研究目的：研究经尿道前列腺等离子双极电切术(PKRP)在前列腺增生患者(前列腺体积大于80g)中应用和临床效果及比较PKRP对不同前列腺体积患者治疗效果。方法：回顾性分析2011年1月-2011年12月在我院泌尿外科经PRKP治疗后的前列腺增生患者(前列腺体积大于80g)的临床资料,收集患者的基本信息,包括术前指标(年龄、前列腺大小、Qmax、残余尿量、IPSS、fPSA、fPSA血Hb、血Na+)和术后指标(住院天数(h)、手术时间(min)、置管时间、有无再手术、有无输血)同时按照前列腺体积将上述患者分为两组：80-100g和100g以上。通过对上述两组年龄、前列腺大小、Qmax、残余尿量、IPSS、fPSA、fPSA、血Hb、血Na+、住院天数(h)、手术时间(min)、置管时间等结果进行t检验并统计分析,对在手术和输血行卡方检验,P0.05两组间差异具有统计学意义。结果：纳入经PKRP术后患者40例,手术过程顺利。40例PKRP术后病理报告均为良性前列腺增生。经PKRP手术治疗的患者年龄为(72.3±6.65)岁,术前前列腺大小为(101.05±18.78) g,Qmax(7.25±2.62) ml/s,残余尿量(131.09± 139.63) ml, IPSS(19.97±7.12),Total PSA (13.11±12.31) ng/L, f/t PSA (0.226±0.082),术前Hb(129.65±11.58)g/L,术前血Na+(141.34±2.62) mmol/L,总手术时间(112±40.62)min,切除重量(60±17.02)g,住院时间(25.475±8.464)天,置管时间(166.05±91.09)h。术后1例因出血再手术,6例术后需要输血,无TUR综合征的发生。不同大小的前列腺增生患者经尿道前列腺等离子双极电切术后显示,80-100g前列腺组(n=23)和100g以上前列腺组(n=1 7)经PKRP术后在切除重量(51.52±11.02g vs.71.47±17.21g)、住院天数(23.17±7.50d vs.28.59±8.91d)、再手术(0 vs.1)和输血例数(0 vs.6)有显著的统计学差异(P0.05)。35例患者完成电话随访,随访时间为术后5-17个月,IPSS评分为2.51±1.15,仅一例患者述勃起功能较术前稍差。出院后无患者需要再手术。无患者发生尿失禁,7例患者有逆行射精,有20例发生了泌尿系感染。结论：PKRP术治疗前列腺体积大于80g的前列腺增生是安全有效的,通过将生理盐水作为术中冲洗液,它明显消除了TUR综合征的发生危险,且对性功能无明显影响。PKRP是治疗大前列腺的一种有前景的形式。它应在泌尿外科界内更多的推广和应用。第三部分Bcl-2蛋白表达与中国人群前列腺癌风险相关性的Meta分析目的：采用：neta分析的方法系统评价Bcl-2蛋白表达与中国人群前列腺癌及其不同临床病理特征的相关性。方法：计算机检索PubMed、Embase、CBM、CNKI、VIP和WanFang Data数据库,查找关于Bcl-2蛋白表达与中国人群前列腺癌及其不同临床病理特征相关性的病例-对照研究,检索时限均为从建库至2016年3月。由2位评价者独立进行文献筛选、资料提取和方法学质量评价,然后采用RevMan 5.3软件进行Meta分析。结果：最终纳入24个病例-对照研究,其中前列腺癌患者1081例,正常前列腺对照178例。Meta分析结果显示：前列腺癌患者Bcl-2蛋白的表达量高于前列腺增生患者[OR=3.27,95%CI(1.68,6.38),P=0.0005],且高于正常前列腺对照[OR=3.77,95%CI (1.81,7.88),P=0.0004],差异均有统计学意义;前列腺癌中低分化组Bcl-2蛋白的表达量高于高分组[OR=3.60,95%CI(2.51,5.16),P0.00001]、前列腺癌J-W-P分期C+D期组组Bcl-2蛋白的表达量高于A+B期组[OR=2.17,95%CI(1.23,3.84),P=0.008]、前列腺癌伴转移组Bcl-2蛋白的表达量高于不伴转移组[OR=4.02,95%CI(1.85,8.75), P=0.0005],差异均有统计学意义。结论：Bcl-2蛋白表达与中国人群前列腺癌及其临床病理特征有显著相关性。受纳入研究样本量和质量限制,上述结论需进一步开展大样本、高质量研究加以验证。第四部分E-cadherin表达与中国人群前列腺癌风险相关性的Meta分析目的：采用neta分析的方法系统评价E-cadherin表达与中国人群前列腺癌及其不同临床病理特征的相关性。方法：计算机检索PubMed、Embase、CBM、CNKI、VIP和WanFang Data数据库,搜集关于E-cadherin表达与中国人群前列腺癌及其不同临床病理特征相关性的临床研究,检索时限均为从建库至2015年12月。由2位评价者按纳入排除标准独立进行文献筛选和资料提取,然后采用RevMan5.3软件进行Meta分析。结果：最终纳入21个研究,其中前列腺癌组920例,前列腺增生组415例,正常前列腺组织组48例。Meta分析结果显示,E-cadherin在前列腺癌组的表达显著低于前列腺增生组[OR=0.07,95%CI(0.05,0.11),P0.01]和正常前列腺组织组[OR=0.04, 95%CI (0.01,0.18), P0.01],且E-cadherin在前列腺癌组织中的表达随着前列腺癌病理分级和临床分期的增加、伴淋巴结或骨转移及血清PSA水平的增加而逐渐降低。结论：E-cadherin低表达与中国人群前列腺癌及其临床病理特征有显著相关性。受纳入研究样本量和质量限制,该结论需进一步高质量开展研究加以验证。第五部分Survivin蛋白表达与中国人群前列腺癌风险相关性的Meta分析目的：采用Meta分析的方法评价Survivin蛋白表达与中国人群前列腺癌及其不同临床病理特征的相关性。方法：计算机检索PubMed、Embase、CBM、CNKI、VIP和WanFang Data数据库,查找关于Survivin蛋白表达与中国人群前列腺癌及其不同临床病理特征相关性的病例-对照研究,检索时限均为从建库至2015年11月。由2位作者按纳入排除标准独立进行文献筛选、资料提取和方法学质量评价,然后采用RevMan 5.3软件进行Meta分析。结果：最终纳入32个病例-对照研究,其中前列腺癌组1613例,前列腺增生组708例,正常前列腺组织组93例。Meta分析结果显示：Survivin蛋白在前列腺癌组与前列腺增生组[OR=32.95,95%CI(19.88,54.63),P0.01]、前列腺癌组与正常前列腺组织组[OR=75.78,95%CI(26.97,212.98),P0.01]的表达差异均有统计学意义；Survivin蛋白在前列腺癌中低分化组与高分组[OR=4.45,95%CI (3.13,6.32), P0.01],前列腺癌J-W-P分期C+D期组与A+B期组[OR=5.42,95%CI (2.91,10.10), P0.01],伴淋巴结转移组与不伴淋巴结转移组[OR=4.07,95%CI (2.91,10.10), P0.01]的表达差异均有统计学意义。结论：Survivin蛋白表达与中国人群前列腺癌及其临床病理特征有显著相关性。受纳入研究样本量和质量限制,上述结论需进一步开展研究加以验证。
[Abstract]:Part 1 a comparative study of the effects of domestic and imported plasma bipolar electrotangent rings on the histopathology of prostatic prostate in dogs. Objective: To compare the histopathological effects of domestic and imported plasma bipolar rings on the histopathology of the prostate in dogs. Methods: 18 adult male hybrid dogs were randomly divided into 2 groups: the imported electric cutting ring group (9), and the domestic electric cut ring group (9 0 after the operation (immediately after the operation), the animals were sacrificed at 1,6 weeks and the prostate specimens were obtained. The pathological changes of the prostate tissue were observed under the light microscope and the thickness of the solidified layer of the wound was measured. Results: the thickness of the coagulation layer of the prostate tissue in the imported electric cutting ring group and the domestic electric cutting ring group was (235.45 + 25.37) mu m respectively, (110.87 +). 20.23) mu m and (238.12 + 32.47) mu m, (112.64 + 18.76) mu m, there was no significant difference in the two groups after the operation (P0.05). 6 weeks after the operation, the coagulation layer of the wound surface of the prostate tissue in the imported electric cutting ring group and the domestic electrocut ring group was completely off, and the wound was covered with the regenerated urinary tract epithelium. After 0,1,6 weeks after the operation, the imported electric cutting ring group and the domestic electric cutting ring group were in the forefront. The adenoid tissues have different degrees of inflammation, the dilatation of the lumen and the destruction of the epithelium under the solidified layer. Conclusion: the pathological effects of the imported electrotangent ring and the domestic electrotangent ring on the wound of the prostate tissue are basically similar. The application of second parts of the prostatic plasma bipolar electrocutting technique in the treatment of large volume prostatic hyperplasia (80g) Objective: To study the application and clinical effect of transurethral prostatic plasma bipolar electrosurgical resection (PKRP) in patients with prostatic hyperplasia (prostate volume greater than 80g) and to compare the therapeutic effect of PKRP on patients with different prostate volumes. Methods: a retrospective analysis of the prostatic hyperplasia in the Department of Urology of our hospital in December January 2011 after the treatment of PRKP in the Department of urology. The basic information of the patients (prostate volume greater than 80g) was collected, including preoperative parameters (age, size of the prostate, Qmax, residual urine, IPSS, fPSA, fPSA blood Hb, blood Na+) and postoperative index (hospitalization days (H), operation time (min), catheterization time, reoperation, or blood transfusion) at the same time according to the volume of the prostate. Two groups: 80-100g and 100g. Through the above two groups of age, the size of the prostate, Qmax, residual urine, IPSS, fPSA, fPSA, blood Hb, blood Na+, the days of hospitalization (H), operation time (min), tube time and other results were carried out t test and statistical analysis, the difference between the two groups of the two groups was statistically significant. 40 patients were treated with PKRP, and the pathological report of.40 PKRP after operation was benign prostatic hyperplasia. The age of the patients treated with PKRP was (72.3 + 6.65) years old. The size of the prostate was (101.05 + 18.78) g, Qmax (7.25 + 2.62) ml/s, residual urine volume (131.09 + 139.63) ml, IPSS (19.97 + 7.12), Total PSA (13.11 + 12.31) ng/. L, f/t PSA (0.226 + 0.082), preoperative Hb (129.65 + 11.58) g/L, preoperative blood Na+ (141.34 + 2.62) mmol/L, total operation time (112 + 40.62) min, resection weight (60 + 17.02) g, hospitalization time (25.475 + 8.464) days, and catheterization time (166.05 + 91.09) H. after surgery for bleeding and reoperation. After transurethral resection of the prostate, the patients with adenosine hyperplasia showed that the 80-100g prostatic group (n=23) and the prostate group above 100g (n=1 7) were excised (51.52 + 11.02g vs.71.47 + 17.21g) after PKRP, and the number of hospitalized days (23.17 + 7.50d vs.28.59 +. 8.91d), and the number of reoperations (0 vs.1) and the number of blood transfusion (0) had significant statistical differences. P0.05).35 patients were followed up by telephone. The follow-up time was 5-17 months after the operation, and the IPSS score was 2.51 + 1.15. Only one case had a slightly worse erectile function than before the operation. No patients needed reoperation after discharge. No patients had urinary incontinence, 7 patients had retrograde ejaculation and 20 cases of urinary tract infection. Conclusion: PKRP was used to treat the large volume of prostate. The prostatic hyperplasia at 80g is safe and effective. By using saline as an intraoperative irrigation fluid, it clearly eliminates the risk of TUR syndrome and has no obvious effect on sexual function..PKRP is a promising form for the treatment of the large prostate. It should be more popularized and applied in the Department of urology. The third part of the Bcl-2 protein expression should be expressed. Meta analysis of the risk of prostate cancer risk in Chinese people: use the NETA analysis method to systematically evaluate the correlation between Bcl-2 protein expression and the different clinicopathological features of prostate cancer in Chinese population. Methods: PubMed, Embase, CBM, CNKI, VIP and WanFang Data databases were retrieved by computer to search for the expression of Bcl-2 protein. A case-control study on the correlation between prostate cancer and its different clinicopathological features in Chinese people, the retrieval time was from the establishment of the library to March 2016. 2 evaluators were selected independently, the data extraction and the methodological quality evaluation, and then the RevMan 5.3 software for Meta analysis. Results: the final inclusion of 24 case control studies, Among the 1081 cases of prostate cancer and 178 cases of normal prostate control, the results of.Meta analysis showed that the expression of Bcl-2 protein in prostate cancer patients was higher than that of [OR=3.27,95%CI (1.68,6.38), P=0.0005], and [OR=3.77,95%CI (1.81,7.88) and P=0.0004], and the difference was statistically significant higher than that of normal prostate control; in prostate cancer, the prostate cancer was statistically significant. The expression of Bcl-2 protein in low differentiation group was higher than that of high group [OR=3.60,95%CI (2.51,5.16), P0.00001]. The expression of Bcl-2 protein in J-W-P stage group C+D group was higher than that of A+B stage group [OR=2.17,95%CI (1.23,3.84), P=0.008], and the expression of Bcl-2 protein in prostate cancer group was higher than that of non metastasis group. Conclusion: there is a significant correlation between the expression of Bcl-2 protein and the prostatic cancer and its clinicopathological features in Chinese population. The above conclusions need to be further developed and verified by high quality research. The fourth part of E-cadherin expression is related to the risk of prostate cancer in Chinese population. Meta analysis objective: to systematically evaluate the correlation between E-cadherin expression and the different clinicopathological features of prostate cancer in Chinese population by NETA analysis. Methods: the database of PubMed, Embase, CBM, CNKI, VIP and WanFang Data was retrieved by computer to collect the expression of prostate cancer and its different clinical diseases in Chinese population. The clinical study of the correlation of physical characteristics was from the establishment of the library to December 2015. The 2 evaluators were selected and extracted independently according to the exclusion criteria. Then the Meta analysis was carried out by RevMan5.3 software. Results: the results were included in 21 studies, including 920 cases of prostate cancer, 415 cases of prostatic hyperplasia and normal prostate. The results of.Meta analysis in 48 cases of tissue group showed that the expression of E-cadherin in prostate cancer group was significantly lower than that of [OR=0.07,95%CI (0.05,0.11), P0.01] and normal prostate tissue [OR=0.04, 95%CI (0.01,0.18), P0.01], and the expression of E-cadherin in prostate cancer tissue was increased with the pathological grading and clinical stage of prostate cancer. Conclusion: there is a significant correlation between the low expression of E-cadherin and the clinicopathological characteristics of prostate cancer in Chinese population and its clinicopathological features. The conclusion needs further high quality research to be verified. The fifth part of the expression of Survivin protein and the expression of Survivin protein in the Chinese population Meta analysis of the risk related prostate cancer risk in Chinese people: Meta analysis was used to evaluate the correlation between the expression of Survivin protein and the different clinicopathological features of prostate cancer in Chinese population. Methods: the database of PubMed, Embase, CBM, CNKI, VIP and WanFang Data was retrieved by computer to search for the expression of Survivin protein and China A case control study of the correlation between prostate cancer and its different clinicopathological features was studied. The retrieval time was from the establishment of the library to November 2015. 2 authors were screened independently by the inclusion criteria, the data extraction and the quality evaluation were evaluated, and the RevMan 5.3 software was used for the Meta analysis. The results were included in the final 32 cases. In the control study, 1613 cases of prostate cancer, 708 cases of prostatic hyperplasia and 93 cases of normal prostate tissue group.Meta analysis showed that the expression of Survivin protein in prostate cancer group and prostatic hyperplasia group [OR=32.95,95%CI (19.88,54.63), P0.01], prostate cancer group and normal prostatic gland group [OR=75.78,95%CI (26.97212.98), P0.01] expression. The differences were statistically significant, Survivin protein in the low differentiation group and the high group [OR=4.45,95%CI (3.13,6.32), P0.01], J-W-P stage C+D group and A+B stage [OR=5.42,95%CI (2.91,10.10), P0.01], lymph node metastasis group and no lymph node metastasis group [OR=4.07,95%CI (2.91,10.10), differences in expression. Conclusion: there is a significant correlation between the expression of Survivin protein and the prostatic cancer and its clinicopathological features in Chinese population.
【学位授予单位】：武汉大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R699.8
本文编号：2137117
[Abstract]:Part 1 a comparative study of the effects of domestic and imported plasma bipolar electrotangent rings on the histopathology of prostatic prostate in dogs. Objective: To compare the histopathological effects of domestic and imported plasma bipolar rings on the histopathology of the prostate in dogs. Methods: 18 adult male hybrid dogs were randomly divided into 2 groups: the imported electric cutting ring group (9), and the domestic electric cut ring group (9 0 after the operation (immediately after the operation), the animals were sacrificed at 1,6 weeks and the prostate specimens were obtained. The pathological changes of the prostate tissue were observed under the light microscope and the thickness of the solidified layer of the wound was measured. Results: the thickness of the coagulation layer of the prostate tissue in the imported electric cutting ring group and the domestic electric cutting ring group was (235.45 + 25.37) mu m respectively, (110.87 +). 20.23) mu m and (238.12 + 32.47) mu m, (112.64 + 18.76) mu m, there was no significant difference in the two groups after the operation (P0.05). 6 weeks after the operation, the coagulation layer of the wound surface of the prostate tissue in the imported electric cutting ring group and the domestic electrocut ring group was completely off, and the wound was covered with the regenerated urinary tract epithelium. After 0,1,6 weeks after the operation, the imported electric cutting ring group and the domestic electric cutting ring group were in the forefront. The adenoid tissues have different degrees of inflammation, the dilatation of the lumen and the destruction of the epithelium under the solidified layer. Conclusion: the pathological effects of the imported electrotangent ring and the domestic electrotangent ring on the wound of the prostate tissue are basically similar. The application of second parts of the prostatic plasma bipolar electrocutting technique in the treatment of large volume prostatic hyperplasia (80g) Objective: To study the application and clinical effect of transurethral prostatic plasma bipolar electrosurgical resection (PKRP) in patients with prostatic hyperplasia (prostate volume greater than 80g) and to compare the therapeutic effect of PKRP on patients with different prostate volumes. Methods: a retrospective analysis of the prostatic hyperplasia in the Department of Urology of our hospital in December January 2011 after the treatment of PRKP in the Department of urology. The basic information of the patients (prostate volume greater than 80g) was collected, including preoperative parameters (age, size of the prostate, Qmax, residual urine, IPSS, fPSA, fPSA blood Hb, blood Na+) and postoperative index (hospitalization days (H), operation time (min), catheterization time, reoperation, or blood transfusion) at the same time according to the volume of the prostate. Two groups: 80-100g and 100g. Through the above two groups of age, the size of the prostate, Qmax, residual urine, IPSS, fPSA, fPSA, blood Hb, blood Na+, the days of hospitalization (H), operation time (min), tube time and other results were carried out t test and statistical analysis, the difference between the two groups of the two groups was statistically significant. 40 patients were treated with PKRP, and the pathological report of.40 PKRP after operation was benign prostatic hyperplasia. The age of the patients treated with PKRP was (72.3 + 6.65) years old. The size of the prostate was (101.05 + 18.78) g, Qmax (7.25 + 2.62) ml/s, residual urine volume (131.09 + 139.63) ml, IPSS (19.97 + 7.12), Total PSA (13.11 + 12.31) ng/. L, f/t PSA (0.226 + 0.082), preoperative Hb (129.65 + 11.58) g/L, preoperative blood Na+ (141.34 + 2.62) mmol/L, total operation time (112 + 40.62) min, resection weight (60 + 17.02) g, hospitalization time (25.475 + 8.464) days, and catheterization time (166.05 + 91.09) H. after surgery for bleeding and reoperation. After transurethral resection of the prostate, the patients with adenosine hyperplasia showed that the 80-100g prostatic group (n=23) and the prostate group above 100g (n=1 7) were excised (51.52 + 11.02g vs.71.47 + 17.21g) after PKRP, and the number of hospitalized days (23.17 + 7.50d vs.28.59 +. 8.91d), and the number of reoperations (0 vs.1) and the number of blood transfusion (0) had significant statistical differences. P0.05).35 patients were followed up by telephone. The follow-up time was 5-17 months after the operation, and the IPSS score was 2.51 + 1.15. Only one case had a slightly worse erectile function than before the operation. No patients needed reoperation after discharge. No patients had urinary incontinence, 7 patients had retrograde ejaculation and 20 cases of urinary tract infection. Conclusion: PKRP was used to treat the large volume of prostate. The prostatic hyperplasia at 80g is safe and effective. By using saline as an intraoperative irrigation fluid, it clearly eliminates the risk of TUR syndrome and has no obvious effect on sexual function..PKRP is a promising form for the treatment of the large prostate. It should be more popularized and applied in the Department of urology. The third part of the Bcl-2 protein expression should be expressed. Meta analysis of the risk of prostate cancer risk in Chinese people: use the NETA analysis method to systematically evaluate the correlation between Bcl-2 protein expression and the different clinicopathological features of prostate cancer in Chinese population. Methods: PubMed, Embase, CBM, CNKI, VIP and WanFang Data databases were retrieved by computer to search for the expression of Bcl-2 protein. A case-control study on the correlation between prostate cancer and its different clinicopathological features in Chinese people, the retrieval time was from the establishment of the library to March 2016. 2 evaluators were selected independently, the data extraction and the methodological quality evaluation, and then the RevMan 5.3 software for Meta analysis. Results: the final inclusion of 24 case control studies, Among the 1081 cases of prostate cancer and 178 cases of normal prostate control, the results of.Meta analysis showed that the expression of Bcl-2 protein in prostate cancer patients was higher than that of [OR=3.27,95%CI (1.68,6.38), P=0.0005], and [OR=3.77,95%CI (1.81,7.88) and P=0.0004], and the difference was statistically significant higher than that of normal prostate control; in prostate cancer, the prostate cancer was statistically significant. The expression of Bcl-2 protein in low differentiation group was higher than that of high group [OR=3.60,95%CI (2.51,5.16), P0.00001]. The expression of Bcl-2 protein in J-W-P stage group C+D group was higher than that of A+B stage group [OR=2.17,95%CI (1.23,3.84), P=0.008], and the expression of Bcl-2 protein in prostate cancer group was higher than that of non metastasis group. Conclusion: there is a significant correlation between the expression of Bcl-2 protein and the prostatic cancer and its clinicopathological features in Chinese population. The above conclusions need to be further developed and verified by high quality research. The fourth part of E-cadherin expression is related to the risk of prostate cancer in Chinese population. Meta analysis objective: to systematically evaluate the correlation between E-cadherin expression and the different clinicopathological features of prostate cancer in Chinese population by NETA analysis. Methods: the database of PubMed, Embase, CBM, CNKI, VIP and WanFang Data was retrieved by computer to collect the expression of prostate cancer and its different clinical diseases in Chinese population. The clinical study of the correlation of physical characteristics was from the establishment of the library to December 2015. The 2 evaluators were selected and extracted independently according to the exclusion criteria. Then the Meta analysis was carried out by RevMan5.3 software. Results: the results were included in 21 studies, including 920 cases of prostate cancer, 415 cases of prostatic hyperplasia and normal prostate. The results of.Meta analysis in 48 cases of tissue group showed that the expression of E-cadherin in prostate cancer group was significantly lower than that of [OR=0.07,95%CI (0.05,0.11), P0.01] and normal prostate tissue [OR=0.04, 95%CI (0.01,0.18), P0.01], and the expression of E-cadherin in prostate cancer tissue was increased with the pathological grading and clinical stage of prostate cancer. Conclusion: there is a significant correlation between the low expression of E-cadherin and the clinicopathological characteristics of prostate cancer in Chinese population and its clinicopathological features. The conclusion needs further high quality research to be verified. The fifth part of the expression of Survivin protein and the expression of Survivin protein in the Chinese population Meta analysis of the risk related prostate cancer risk in Chinese people: Meta analysis was used to evaluate the correlation between the expression of Survivin protein and the different clinicopathological features of prostate cancer in Chinese population. Methods: the database of PubMed, Embase, CBM, CNKI, VIP and WanFang Data was retrieved by computer to search for the expression of Survivin protein and China A case control study of the correlation between prostate cancer and its different clinicopathological features was studied. The retrieval time was from the establishment of the library to November 2015. 2 authors were screened independently by the inclusion criteria, the data extraction and the quality evaluation were evaluated, and the RevMan 5.3 software was used for the Meta analysis. The results were included in the final 32 cases. In the control study, 1613 cases of prostate cancer, 708 cases of prostatic hyperplasia and 93 cases of normal prostate tissue group.Meta analysis showed that the expression of Survivin protein in prostate cancer group and prostatic hyperplasia group [OR=32.95,95%CI (19.88,54.63), P0.01], prostate cancer group and normal prostatic gland group [OR=75.78,95%CI (26.97212.98), P0.01] expression. The differences were statistically significant, Survivin protein in the low differentiation group and the high group [OR=4.45,95%CI (3.13,6.32), P0.01], J-W-P stage C+D group and A+B stage [OR=5.42,95%CI (2.91,10.10), P0.01], lymph node metastasis group and no lymph node metastasis group [OR=4.07,95%CI (2.91,10.10), differences in expression. Conclusion: there is a significant correlation between the expression of Survivin protein and the prostatic cancer and its clinicopathological features in Chinese population.
【学位授予单位】：武汉大学
【学位级别】：博士
【学位授予年份】：2016
【分类号】：R699.8
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