保留动脉显微手术联合麒麟丸治疗双侧精索静脉曲张致少弱精子症

发布时间：2018-07-22 11:08

【摘要】：目的:探讨保留睾丸动脉显微手术联合服用麒麟丸治疗双侧精索静脉曲张(VC)合并少弱精子症的临床疗效。方法:60例双侧精索静脉曲张并少弱精子症患者,随机分为两组,单纯手术组30例,显微手术联合服用麒麟丸组30例,疗程12周,每次服用6 g,每日3次,观察治疗后第4、8、12周两组患者精子浓度、精液量、精子活力(a+b级)、畸形精子百分率、血清Inh B、LH、TT和FSH水平变化,并计算睾酮分泌指数(TSI=TT/LH)。结果:患者均手术成功,术后症状消失,精子浓度、精液量、精子活力明显提高,畸形精子百分率明显降低,术后血清Inh B、TT、TSI明显改善,FSH、LH含量降低,与术前比较,差异有统计学意义(P㩳0.01)。手术联合服用麒麟丸组治疗12周后血清Inh B、LH、TT及TSI分别为(138.96±22.26)ng/L、(3.17±0.12)IU/L、(13.98±3.02)nmol/L、(4.41±0.53)nmol/IU,单纯手术组治疗12周后分别为(129.54±22.23)ng/L、(3.59±0.11)IU/L、(12.68±3.12)nmol/L、(3.53±0.51)nmol/IU,两组间对比差异有显著性(P㩳0.05)。手术联合服用麒麟丸组受孕22例,受孕率为73.4%,比单纯手术组受孕11例、受孕率为36.6%效果显著(P㩳0.05)。结论:保留睾丸动脉显微手术联合服用麒麟丸治疗双侧精索静脉曲张所致少弱精子症,对于术后精液质量改善明显、疗效满意。
[Abstract]:Objective: to investigate the clinical effect of testicular artery preserving microsurgery combined with Kirin pill in the treatment of bilateral varicocele (VC) with oligozoospermia. Methods Sixty patients with bilateral varicocele and oligozoospermia were randomly divided into two groups: 30 cases in simple operation group and 30 cases in Kirin pill group. The course of treatment was 12 weeks. The sperm concentration, spermatozoa volume, sperm motility (a b grade), abnormal sperm percentage, serum InhB LHH TT and FSH levels were observed and the testosterone secretion index (TSI TT / LH) was calculated at the 12th week after treatment. Results: all the patients were successfully operated, the symptoms disappeared, the sperm concentration, spermatozoa volume, sperm motility increased, the percentage of abnormal spermatozoa decreased, and the serum Inh Btrot TSI significantly improved the decrease of FSH LH after operation, which was compared with that before operation. The difference was statistically significant (P0. 01). After 12 weeks of treatment, the serum levels of serum Inh Btrope LHHHHNTT and TSI were (138.96 卤22.26) ng / L, (3.17 卤0.12) nmol / L, (13.98 卤3.02) nmol / L, (4.41 卤0.53) nmol / L respectively in the operation group, and (129.54 卤22.23) ng / L, (3.59 卤0.11) nmol / L, (12.68 卤3.12) nmol / L, (3.53 卤0.51) nmol / L in the operation group, respectively. The pregnancy rate was 73.4% in the operation combined with Kirin pill group, which was significantly higher than that in the operation group (36.6%) (P 0.05). Conclusion: the treatment of oligozoospermia caused by varicocele by preserving testicular artery microsurgery combined with Kirin pill is satisfactory for the improvement of semen quality after operation.
【作者单位】：青州市人民医院/青岛大学医疗集团青州医院泌尿外科;潍坊医学院附属益都中心医院中心实验室;
【分类号】：R699

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