中药微调五号方联合生物反应调节剂对肾癌患者肿瘤标志物及生活质量的影响

发布时间：2018-07-24 15:28

【摘要】：目的:分析中药微调五号方联合生物反应调节剂重组人白介素-2(IL-2)、重组人干扰素α2b(IFN-α2b)对肾癌患者肿瘤标志物及生活质量的影响。方法:将50例肾癌患者用双盲法分为对照组(IFN-α2b、IL-2皮下注射)、观察组(加用中药微调五号)。统计客观疗效中缓解率、治疗前后肿瘤标志物水平、T细胞亚群主要指标变化,记录QLQ-C30生命质量、生活质量卡氏评分(KPS)分值,记录Ⅲ度、Ⅵ度不良反应发生率。结果:治疗后,观察组缓解率(24.00%)与对照组无显著差异,P0.05;观察组NSE低于对照组;观察组CD_4~+升高,CD_8~+下降,CD_4~+/CD_8~+升高,均优于对照组;观察组除认知功能分值外QLQ-C30其它指标分值均高于对照组;观察组卡氏评分高于对照组;观察组Ⅲ度、Ⅵ度不良反应发生率(4.00%)低于对照组。均P0.05。结论:中药微调五号联合生物反应调节剂能显著抑制部分肿瘤标志物,提高患者免疫力,改善生命质量和生活质量,减少严重不良反应,值得推广。
[Abstract]:Aim: to analyze the effect of the combination of the Chinese herbal medicine Weijiao No. 5 recipe and the biological response regulator recombinant human interleukin-2 (IL-2) and recombinant human interferon 伪 2b (IFN- 伪 2b) on tumor markers and quality of life in patients with renal cell carcinoma (RCC). Methods: 50 patients with renal cell carcinoma were divided into control group (IFN- 伪 2bC-2 subcutaneous injection) and observation group (treated with Chinese herbal fine tuning 5) by double blind method. The remission rate of objective curative effect, the changes of tumor marker level and T cell subsets before and after treatment, the quality of life (QOL) of QLQ-C30, the (KPS) score of quality of life (QOL), the incidence of adverse reactions (鈪，

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