膀胱癌患者手术前后血清前梯度蛋白水平变化及其预后判断价值

发布时间：2018-07-24 16:35

【摘要】：目的:检测膀胱癌患者手术前后血清前梯度蛋白2(anterior gradient 2,AGR2)的水平变化,并探讨其预后判断价值。方法:采集厦门大学附属成功医院2013年6月至2015年12月40例行手术治疗的膀胱癌患者(膀胱癌组)和20例健康体检者(对照组)外周静脉血,采用ELISA法检测血清AGR2水平,分析血清AGR2水平与膀胱癌临床病理特征及预后的关系。结果:膀胱癌组患者术前血清AGR2水平明显高于正常对照组[(28.93±6.03)vs(10.20±3.76)ng/ml,P0.01],术后血清AGR2水平明显低于手术前[(16.63±4.31)vs(28.93±6.03)ng/ml,P0.01〗;患者术前血清AGR2水平与临床病理分期、淋巴结转移有关(P0.05或P0.01),术前血清AGR227.9 ng/ml组中位患者PFS与OS均明显低于≤27.9 ng/ml组(P0.05);COX模型多因素分析结果显示,病理分期、淋巴结转移以及不同AGR2水平是影响膀胱癌患者预后的独立危险因素(P0.05)。结论:膀胱癌患者血清AGR2水平增高,其与膀胱癌的恶性生物学行为有关,术前检测血清AGR2水平对于判断膀胱癌患者预后有一定临床价值。
[Abstract]:Objective: to detect the changes of serum pregradient protein 2 (anterior gradient 2 AGR2 in patients with bladder cancer before and after operation, and to evaluate its prognostic value. Methods: peripheral venous blood samples were collected from 40 patients with bladder cancer (bladder cancer group) and 20 healthy persons (control group) from June 2013 to December 2015, and the serum AGR2 levels were measured by ELISA method. To analyze the relationship between serum AGR2 level and clinicopathological features and prognosis of bladder cancer. Results: the preoperative serum AGR2 level in bladder cancer group was significantly higher than that in normal control group [(28.93 卤6.03) vs (10.20 卤3.76) ng / ml P0.01], and the postoperative serum AGR2 level was significantly lower than that before operation [(16.63 卤4.31) vs (28.93 卤6.03) ng / ml P0.01]. Lymph node metastasis was related (P0.05 or P0.01). PFS and OS were significantly lower in preoperative AGR227.9 ng/ml group than in 鈮，

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