慢性肾脏病患者神经肽Y与营养状态和心血管事件的相关性

发布时间：2018-08-12 09:31

【摘要】：目的:观察非透析慢性肾脏病(CKD)患者神经肽Y(NPY)与营养状态和心血管事件的关系。方法:通过队列研究方法,采用线性相关分析脑脊液和血清NPY水平与营养状态的关系;采用受试者工作特征(ROC)曲线分析脑脊液NPY水平对CKD患者营养状态的诊断能力;采用生存分析法研究血清NPY水平和心血管事件的关系。结果:血清NPY水平与IL-6、胆固醇呈正相关(P0.05);脑脊液NPY水平与e GFR、血清前白蛋白、MAMC及能量摄入量呈正相关(P0.05);脑脊液NPY评价营养状态的敏感性和特异性分别为79.9%、58.2%;生存分析结果显示血清NPY与心血管事件显著相关(HR=1.801 5,CI:1.050 9~3.088 1)。结论:CKD患者脑脊液NPY水平和营养状态相关,高血清NPY水平可能是心血管事件的危险因素之一。
[Abstract]:Objective: to investigate the relationship between neuropeptide Y (NPY) and nutritional status and cardiovascular events in patients with non-dialysis chronic kidney disease (CKD). Methods: linear correlation analysis was used to analyze the relationship between cerebrospinal fluid (CSF) and serum NPY level and nutritional status by cohort study, and the diagnostic ability of cerebrospinal fluid (NPY) level to nutritional status of CKD patients was analyzed by (ROC) curve. Survival analysis was used to study the relationship between serum NPY level and cardiovascular events. Results: serum NPY level was positively correlated with IL-6 and cholesterol (P0.05), cerebrospinal fluid NPY level was positively correlated with eGFR, serum prealbumin MAMCs and energy intake (P0.05), the sensitivity and specificity of CSF NPY in evaluating nutritional status were 79.9% and 58.2%, respectively. The results showed that serum NPY was significantly correlated with cardiovascular events (HR=1.801 5 CI: 1.050 9 / 3.0881). Conclusion the level of cerebrospinal fluid (NPY) is correlated with nutritional status in patients with NPY. High serum NPY level may be one of the risk factors for cardiovascular events.
【作者单位】：南方医科大学中医药学院;南方医科大学中西医结合医院;
【基金】：国家自然科学基金项目(编号:81373808,81573729)
【分类号】：R692

【参考文献】