肾细胞癌中琥珀酸脱氢酶亚单位A和B蛋白的表达缺失

发布时间：2018-08-12 10:45

【摘要】：目的探讨肾细胞癌(RCC)中琥珀酸脱氢酶亚单位A(SDHA)及B(SDHB)的蛋白表达情况及其与临床病理特征之间的关系。方法采用免疫组织化学方法检测179例RCC病例肿瘤组织中这两种蛋白的表达情况及其与该肿瘤临床病理特征之间的关系。结果 179例RCC中,18例SDHA及SDHB表达阴性及可疑阴性,其中SDHA及SDHB均为可疑阴性2例(1.1%)。肿瘤位于左肾12例,右肾6例;高分化组15例(83.3%)、中分化组1例(5.6%)及低分化组2例(11.1%)。大部分SDH阴性及可疑阴性RCC有以下特征:肿瘤内有陷入的正常肾小管,肿瘤细胞为多边形,由菲薄的纤维组织分割成巢,核内染色质呈空泡状,肿瘤细胞胞质内可见嗜酸性絮状物、空泡及嗜酸性包涵体。结论 SDHA和(或)SDHB蛋白表达阴性(缺失)及可疑阴性RCC病例有独特的组织学特征,左肾明显多于右肾,高分化组更常见。
[Abstract]:Objective to investigate the expression of succinate dehydrogenase subunit A (SDHA) and B (SDHB) in renal cell carcinoma (RCC) and its relationship with clinicopathological features. Methods Immunohistochemical method was used to detect the expression of these two proteins in tumor tissues of 179 patients with RCC and their relationship with the clinicopathological features of the tumor. Results there were 18 cases with negative and suspicious negative expression of SDHA and SDHB in 179 cases of RCC, of which SDHA and SDHB were both suspicious negative in 2 cases (1.1%). The tumor was located in the left kidney in 12 cases, in the right kidney in 6 cases, in the well-differentiated group in 15 cases (83.3%), in the moderately differentiated group in 1 case (5.6%) and in the poorly differentiated group in 2 cases (11.1%). Most of the SDH negative and suspicious negative RCC have the following characteristics: the tumor has normal tubules trapped in the tumor, the tumor cells are polygonal, they are divided into nests by thin fibrous tissue, and the chromatin in the nucleus is vacuolated. Eosinophilic flocculants, vacuoles and eosinophilic inclusion bodies were found in the cytoplasm of tumor cells. Conclusion SDHA and / or SDHB protein expression negative (deletion) and suspicious negative RCC cases have unique histological features, the left kidney is more than the right kidney, the high differentiation group is more common.
【作者单位】：贵州医科大学病理学教研室;贵州医科大学附属医院病理科;
【分类号】：R737.11

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