慢性肾脏病患者血清骨保护素水平及与腹主动脉钙化的相关性分析

发布时间：2018-09-03 19:13

【摘要】：目的观察慢性肾脏病(CKD)3-5D期患者血清骨保护素(OPG)变化,并探讨和腹主动脉钙化(AAC)的相关性。方法选取86例CKD 3-5D期患者为研究对象,根据腹主动脉有无钙化分为AAC组和non-AAC组,应用ELISA法测定各组患者血清OPG水平;采用腹部侧位片评估AAC程度。结果 86例CKD患者中AAC 51例(59.3%)。51例ACC患者OPG明显高于35例non-AAC患者(P0.01)。CKD5期未行肾脏替代治疗患者血清OPG显著高于CKD3-4期患者(P0.05);CKD5D期血清OPG水平和CKD5期未行肾脏替代治疗患者OPG差异无统计学意义。血清OPG与e GFR呈显著负相关(r=-0.357,P=0.011),与AAC程度相关(r=0.258,P=0.017)。Logistic回归分析发现:男性(β=2.568,P=0.048)、吸烟(β=4.337,P=0.013)、OPG(β=1.273,P=0.003)是影响AAC的主要因素。结论在CKD患者中,血管钙化发生率高,随着肾功能恶化,血清OPG水平有升高趋势。男性、吸烟及OPG是AAC的危险因素,可能参与AAC的发生与发展。
[Abstract]:Objective to observe the changes of serum osteoprotegerin (OPG) in patients with chronic kidney disease (CKD) 3-5D) and to explore the correlation between serum osteoprotegerin and calcified (AAC) in abdominal aorta. Methods 86 patients with stage 3-5D of CKD were divided into AAC group and non-AAC group according to the calcification of abdominal aorta. The serum OPG level was measured by ELISA method and the degree of AAC was evaluated by abdominal lateral radiography. Results the serum OPG levels of AAC 51 (59.3%) .51 ACC patients with CKD were significantly higher than those of 35 non-AAC patients (P0.01). CKD5 patients without renal replacement therapy (P0.05) and CKD5 patients without renal replacement therapy (CKD5). There was no significant difference in OPG. There was a significant negative correlation between serum OPG and e GFR (r-0.357 P0. 011). Logistic regression analysis showed that: male (尾 -2.568), smoking (尾 4.337), OPG (尾 1.273P0. 003) were the main factors affecting AAC. Conclusion the incidence of vascular calcification is high in patients with CKD, and the serum OPG level tends to increase with the deterioration of renal function. In men, smoking and OPG are risk factors for AAC and may be involved in the occurrence and development of AAC.
【作者单位】：安徽医科大学第二附属医院肾脏内科;
【基金】：高校省级自然科学研究项目(编号:KJ2013Z155)
【分类号】：R692

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