TERT和CLK3基因多态性与膀胱癌的易感性

发布时间：2018-09-10 16:16

【摘要】：目的:探讨TERT基因rs2736098和CLK3基因rs11543198单核苷酸多态性与膀胱癌的易感性关系。方法:选取201例经病理确诊的膀胱癌患者和200例健康人群作为研究对象,用PCR-RFLP方法检测TERTrs2736098和CLK3rs11543198位点的基因型,比较各基因型和膀胱癌发病风险的关系。结果:rs2736098位点基因型及等位基因在病例组和对照组中的分布差异均有统计学意义(χ~2=6.973,P=0.031;χ~2=7.412,P=0.006),AA基因型携带者发生膀胱癌的风险是CC基因型携带者的2.069倍(OR=2.069,95%CI:1.181~3.624,P=0.011)。而rs11543198位点基因型及等位基因在两组中未见明显差异(χ~2=0.202,P=0.904;χ~2=0.188,P=0.665)。rs2736098和rs11543198基因型在膀胱癌病理分期、分级中的分布差异均无统计学意义(P0.05)。结论:TERT基因rs2736098位点多态性与膀胱癌的易感性相关,而CLK3基因rs11543198位点多态性与膀胱癌的发生风险无明显关系。
[Abstract]:Objective: to investigate the relationship between single nucleotide polymorphisms (SNP) of TERT gene rs2736098 and CLK3 gene and susceptibility to bladder cancer. Methods: 201 patients with bladder cancer diagnosed by pathology and 200 healthy people were selected as study subjects. The genotypes of TERTrs2736098 and CLK3rs11543198 were detected by PCR-RFLP method, and the relationship between the genotypes and the risk of bladder cancer was compared. Results there was a statistically significant difference in the distribution of genotype and allele at the 1: rs2736098 locus between the case group and the control group (蠂 ~ 2 / r = 6.973). The risk of bladder cancer in AA genotype carriers was 2.069 times higher than that in CC genotype carriers (蠂 ~ (2) = 6.973) and 蠂 ~ (2 +) = 7.412P ~ (0.006) respectively. The risk of bladder cancer in AA genotype carriers was 2.069 times higher than that in CC genotype carriers (OR=2.069,95%CI:1.181~3.624,P=0.011). However, there was no significant difference in genotype and allele of rs11543198 locus between the two groups (蠂 ~ (2 +) (0.202) P ~ (0.904); 蠂 ~ (2 +) (0.188) P ~ (0.665) .Rs2736098 and rs11543198 genotype had no significant difference in the pathological stage and grade of bladder cancer (P0.05). Conclusion the rs2736098 locus polymorphism of the fraction TERT gene is associated with the susceptibility to bladder cancer, while the rs11543198 locus polymorphism of the CLK3 gene is not associated with the risk of bladder cancer.
【作者单位】：广西医科大学第一附属医院泌尿外科;广西医科大学附属肿瘤医院泌尿外科;
【基金】：广西教育厅科研资助项目(编号:201012MS046)
【分类号】：R737.14

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