少、弱、畸精子症相关遗传基因研究进展

发布时间：2018-09-14 09:57

【摘要】：目前研究发现与精子发生相关的基因约2 300个,其表达在调控精子的发生过程中起着重要的作用。近年来,少、弱、畸精症的相关遗传基因成为研究的热点,相关研究试图从分子水平上探讨少、弱、畸精症发生的机制,并取得了一些成果,一些基因如GSTM1、DNMT3L和CYP1A1可能与少精症的发生有关;一些基因如CATSPER1、CRISP2、SEPT4、TCTE3、TEKT4和DNAH1可能与弱精症的发生有关;一些基因如DPY19L2、AURKC,可能与畸精症的发生有关。这些相关的基因研究为少、弱、畸精症的发病机制提供了可能的分子基础,同时也为探索新的诊治技术提供了新的思路。本文就少、弱、畸精症的部分相关遗传基因的最新研究进展作一综述。
[Abstract]:At present, about 2 300 genes related to spermatogenesis have been found, and their expression plays an important role in the regulation of spermatogenesis. In recent years, few, weak, teratospermia related genetic genes have become the focus of research, related research attempts to explore the molecular level of the mechanism of the occurrence of less, weak, teratospermia, and has achieved some results. Some genes such as GSTM1,DNMT3L and CYP1A1 may be related to the occurrence of oligozoospermia, some genes such as CATSPER1,CRISP2,SEPT4,TCTE3,TEKT4 and DNAH1 may be related to the occurrence of azoospermia, and some genes such as DPY19L2,AURKC, may be related to the occurrence of teratospermia. These related gene studies provide a possible molecular basis for the pathogenesis of rare, weak, and teratospermia, as well as new ideas for exploring new diagnostic and therapeutic techniques. This article reviews the recent research progress of some genetic genes associated with few, weak, and teratospermia.
【作者单位】：兰州大学第二医院泌尿外科研究所甘肃省泌尿系统疾病研究重点实验室甘肃省泌尿系统疾病临床医学中心;甘肃省妇幼保健院男科;
【基金】：国家自然科学基金(81402122) 中华医学会临床医学科研专项资金(14020210558) 甘肃省自然科学基金(1606RJZA167)~~
【分类号】：R698.2

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