他达拉非不同给药方案对初次性生活失败的男性勃起功能障碍患者疗效观察

发布时间：2018-09-18 16:48

【摘要】：目的:评估他达拉非3种不同给药方案对初次性生活失败的年轻男性勃起功能障碍(ED)患者疗效。方法:将夜间阴茎勃起硬度检查正常、心理治疗无效的初次性生活失败的年轻男性ED患者分为他达拉非每日小剂量口服组(每日夜间睡前1~2 h口服他达拉非5 mg)、按需治疗组(性生活前1~2 h口服他达拉非10~20 mg,根据勃起硬度调整剂量)、每日小剂量与按需治疗联合组(无性生活时每日夜间口服他达拉非5 mg,性生活当日于性生活前1~2 h一次性服用他达拉非10~20 mg、其剂量根据勃起硬度确定)共3组,分别给予相应治疗2~3个月。以国际勃起功能指数(IIEF)5个专项评分分别评估疗效。结果:3组IIEF勃起功能、性高潮、插入满意度、总体满意度专项评分较治疗前均显著提高(P均0.05或0.01);按需治疗较每日小剂量治疗显著提高勃起功能和性高潮专项评分(P0.05),但在性欲专项评分方面,其效果低于每日小剂量治疗;当给予联合治疗时,5个专项评分均得到了最佳改善(P均0.05)。结论:由于缺乏专业的性心理治疗机构和医生,单纯心理治疗对心理性ED患者疗效较差,以每日小剂量口服联合按需服用他达拉非可明显提高初次性生活失败的年轻男性ED患者疗效。
[Abstract]:Aim: to evaluate the efficacy of three different drug regimens in the treatment of erectile dysfunction (ED) in young men with primary sexual failure. Methods: the hardness of penile erection was examined at night. Young male ED patients who failed in first sexual life without effective psychotherapy were divided into a small daily oral Tadalafil group (oral Tadalafil 5 mg), per day at 1h before bedtime on demand) (Tadalafil 2 h before sex) Small dose and on-demand treatment group (oral Tadalafil 5 mg, daily at night while not having sex, 1: 2 h before sex), a single dose of tadarafil 1020 mg, on the day of sexual life) (non-10 mg, adjusted dose according to erectile hardness), small dose and on demand treatment group (oral Tadalapide 5 mg, daily while not having sex) The volume was determined by erectile hardness) in three groups. The corresponding treatment was given for 2 ~ 3 months. International erectile function index (IIEF) was used to evaluate the efficacy. Results IIEF erectile function, orgasm, insert satisfaction, The scores of total satisfaction were significantly higher than those before treatment (all P 0.05 or 0.01), and the scores of erectile function and orgasm were significantly higher than those of daily low-dose treatment (P0.05), but the effect of the special score of sexual desire was lower than that of daily low-dose treatment. When combined therapy was given, the five special scores were all best improved (P 0.05). Conclusion: due to the lack of professional psychotherapy institutions and doctors, psychotherapy alone is less effective in patients with psychological ED. Low dose oral administration combined with Tadalafil on demand could significantly improve the efficacy of ED in young men who had failed in their first sexual life.
【作者单位】：上海交通大学医学院附属第九人民医院泌尿外科;
【分类号】：R698

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