Beclin1和LC3在膀胱尿路上皮癌中的表达及意义

发布时间：2018-10-08 11:01

【摘要】：目的探讨Beclin1和微管相关蛋白1轻链3(LC3)在膀胱尿路上皮癌中的表达及两者的相关性。方法通过免疫组化法检测56例膀胱尿路上皮癌和32例正常膀胱组织的Beclin1和LC3表达,对比表达的差异。结果膀胱尿路上皮组织Beclin1阳性表达率为66.1%(37/56),显著低于正常膀胱组织的93.8%(30/32),差异有统计学意义(P0.01),而癌组织中LC3阳性表达率为50%(28/56),亦显著低于正常膀胱组织87.5%(28/32),差异有统计学意义(P0.01);Beclin1和LC3表达均与患者临床分期有关(P0.01),与患者年龄、性别及肿瘤生长方式不具有相关性(P0.05);Beclin1和LC3在膀胱尿路上皮癌中的表达具有正相关性(P0.01)。结论膀胱尿路上皮癌中Beclin1和LC3阳性表达率低于正常膀胱组织,两者可能均与膀胱尿路上皮癌的发生发展有关。
[Abstract]:Objective to investigate the expression of Beclin1 and microtubule-associated protein 1 light chain 3 (LC3) in bladder urothelial carcinoma and their correlation. Methods the expressions of Beclin1 and LC3 in 56 cases of bladder urothelial carcinoma and 32 cases of normal bladder were detected by immunohistochemical method. Results the positive rate of Beclin1 in bladder urinary tract epithelial tissue was 66.1% (37 / 56), which was significantly lower than that in normal bladder tissue (93.8%) (30 / 32) (P0.01). The positive rate of LC3 expression in cancer tissue was 50% (28 / 56), and was significantly lower than that in normal bladder tissue (87.5%) (28 / 32). The expression of Beclin1 and LC3 were correlated with the clinical stage of the patients (P0.01), and with the age of the patients. Gender and tumor growth pattern were not correlated (P0.05) the expression of Beclin1 and LC3 in bladder urothelial carcinoma was positively correlated (P0.01). Conclusion the positive expression rate of Beclin1 and LC3 in bladder urothelial carcinoma is lower than that in normal bladder tissue, both of which may be related to the occurrence and development of bladder urothelial carcinoma.
【作者单位】：安徽医科大学第一附属医院泌尿外科;舒城县人民医院泌尿外科;
【基金】：卫生部国家临床重点专科建设项目
【分类号】：R737.14

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