慢性肾脏病患者血清Klotho平与肾功能损害的相关性

发布时间：2018-10-08 19:51

【摘要】：目的:探讨慢性肾脏病(chronic kidney disease,CKD)患者血清Klotho水平与肾功能损害的相关性。方法:收集100例CKD 1~5期的住院患者及30例健康对照者,采用ELISA法检测血清Klotho水平,观察血清Klotho水平及其与肾功能损害的关系。结果:对照组血清Klotho水平9.81(7.45,12.2)ng/m L,CKD患者血清Klotho水平2.97(1.75,5.23)ng/m L,两组比较差异有统计学意义(P0.01);随着肾功能进展,Klotho水平逐渐降低(P0.01);Pearson相关分析显示,CKD患者血清logKlotho水平与肾小球滤过率(e GFR)、血钙、血红蛋白呈正相关,与年龄、log肌酐、logFGF-23以及血磷呈负相关。多元回归分析显示,年龄、logScr、logFGF-23水平是影响血清logKlotho水平的独立危险因素。结论:CKD患者血清Klotho水平随肾功能下降而降低,有望成为CKD患者病情进展的预测指标。
[Abstract]:Objective: to investigate the correlation between serum Klotho level and renal dysfunction in patients with chronic kidney disease (chronic kidney disease,CKD). Methods: serum Klotho levels were measured by ELISA method in 100 inpatients with stage 1 and 5 CKD and 30 healthy controls. The relationship between serum Klotho levels and renal function damage was observed. Results: the serum Klotho level of the control group was 9.81 (7.45 卤12.2). The serum Klotho level was 2.97 (1.75 卤5.23) ng/m L in patients with ng/m LCKD, there was significant difference between the two groups (P0.01), and the serum logKlotho level and the (e GFR), serum calcium level were gradually decreased with the progression of renal function (P0.01). Hemoglobin was positively correlated and negatively correlated with age log creatinine logFGF-23 and blood phosphorus. Multivariate regression analysis showed that the level of logScrus logFGF-23 was an independent risk factor for serum logKlotho levels. Conclusion the level of serum Klotho in patients with CKD decreases with the decrease of renal function, and it is expected to be a predictor of disease progression in patients with CKD.
【作者单位】：江苏大学附属昆山医院肾脏内科;江苏大学附属昆山医院临床实验研究中心;
【基金】：江苏省苏州市"科教兴卫"青年科技项目基金资助项目(编号:KJXW2014049)
【分类号】：R692

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