中长期血液透析联合血液灌流对维持性血液透析患者血管内皮功能的影响

发布时间：2018-10-14 17:20

【摘要】：目的前瞻性观察中长期应用血液透析(HD)联合血液灌流(HP)对维持性血液透析患者的血管内皮功能的保护作用。方法选取我院60例维持性血液透析患者共60例,随机分为两组:HD组和HP联合HD(HP+HD)组。所有患者每周血液透析3次,其中,HP+HD组每周1次血液透析联合血液灌流,共治疗6个月。比较治疗前、治疗3个月及治疗6个月的C反应蛋白(CRP)、血红蛋白(HB)、白蛋白(ALB)、胆固醇(CHOL)、甘油三酯(TG)、血清晚期糖基化终产物(AGEs)、同型半胱氨酸(Hcy)、细胞黏附因子(ICAM)浓度。结果治疗6个月后,HP+HD组的CRP、AGEs、Hcy和ICAM水平均较本组治疗前和HD组治疗后降低(P0.05),HB和ALB均较本组治疗前和HD组增高(P0.05)。两组治疗前后的CHOL及TG差异无统计学意义。结论中长期应用HD联合HP治疗可有效清除AGEs、Hcy及ICAM,并改善营养状态,为减少维持性血液透析患者心血管疾病的发生率,降低死亡率,提高生活质量,提供了安全、简便、有效的治疗途径。
[Abstract]:Objective to observe the protective effect of long-term hemodialysis (HD) combined with hemoperfusion (HP) on vascular endothelial function in maintenance hemodialysis patients. Methods 60 patients with maintenance hemodialysis in our hospital were randomly divided into two groups: HD group and HP combined with HD (HP HD) group. All the patients were treated with hemodialysis 3 times a week. The, HP HD group was treated with hemodialysis and hemoperfusion once a week for 6 months. The serum levels of (AGEs), homocysteine (Hcy), cell adhesion factor (ICAM) were compared before and after treatment for 3 months and 6 months respectively. The serum levels of C-reactive protein (CRP), hemoglobin (HB), albumin (ALB), cholesterol (CHOL), triglyceride (TG), were compared. Results after 6 months of treatment, the levels of CRP,AGEs,Hcy and ICAM in, HP HD group were lower than those before treatment and after treatment in HD group (P0.05), HB and ALB were higher than those before treatment and HD group (P0.05). There was no significant difference in CHOL and TG between the two groups before and after treatment. Conclusion HD combined with HP can effectively remove AGEs,Hcy and ICAM, and improve nutritional status. It can reduce the incidence of cardiovascular disease, reduce mortality, improve quality of life, and provide safety and convenience for maintenance hemodialysis patients. Effective treatment.
【作者单位】：广东省佛山市第一人民医院中山大学附属佛山医院肾内科;
【基金】：佛山市医学类科技攻关项目(编号:2014AB00277)
【分类号】：R692.5

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