血清游离睾酮在勃起功能障碍患者中检测价值的初步探讨

发布时间：2018-10-25 08:01

【摘要】：目的:通过观察勃起功能障碍(ED)患者中血清计算游离睾酮(cFT)、睾酮分泌指数(TSI)及游离睾酮指数(FTI)的变化情况,探讨cFT、TSI、FTI在ED伴雄激素缺乏诊断中的价值。方法:详细询问病史,填写国际勃起功能指数问卷(IIEF-5),完成夜间阴茎勃起功能检测(NPT),根据病史及NPT检查结果纳入实验组及对照组,检测150例NPT结果异常以"ED"为主诉的ED患者及25例NPT结果正常的健康婚检者中血清总睾酮(TT)、黄体生成素(LH)、性激素结合球蛋白(SHBG)和血清白蛋白(ALB),通过公式计算cFT、生物可利用睾酮(Bio-T)、TSI、FTI。以cFT≤0.3 nmol/L、TSI≤2.8、FTI≤0.4为参考截点值,以TT≤11.5 nmol/L为诊断雄激素缺乏的标准,计算出cFT、TSI、FTI的漏诊率、误诊率及符合率。结果:以TT≤11.5 nmol/L为评估标准,诊断20~40岁ED患者雄激素缺乏的符合率分别为cFT 90.8%、TSI 85.8%、FTI 80.8%;诊断20~40岁ED患者雄激素缺乏的漏诊率分别为cFT 4.0%、TSI 33.3%、FTI 44.0%;诊断20~40岁ED患者雄激素缺乏的误诊率分别为cFT 10.5%、TSI9.4%、FTI 12.6%。Kappa值分别为:cFT 0.755、TSI 0.564、FTI 0.427,P均0.05。TT在不同年龄组ED患者中随年龄下降但无统计学差异,cFT、Bio-T、TSI、FTI在不同年龄组ED患者中随年龄下降且具有统计学差异;20~40岁ED患者血清TT、cFT、Bio-T、TSI、FTI在不同IIEF评分组的差别无统计学差异。结论:cFT对20~40岁ED患者伴有雄激素缺乏的检测价值优于TT、TSI及FTI。
[Abstract]:Objective: to investigate the value of cFT,TSI,FTI in the diagnosis of ED with androgen deficiency by observing the changes of serum free testosterone (cFT), testosterone secretion index (TSI) and free testosterone index (FTI) in patients with erectile dysfunction (ED). Methods: the history was inquired in detail, the international erectile function index questionnaire (IIEF-5) was filled out, and the night penile erectile function test (NPT), was completed. According to the history of the disease and the results of NPT examination, the patients were included in the experimental group and the control group. Serum total testosterone, (TT), luteinizing hormone, luteinizing globulin (SHBG) and serum albumin (ALB), were measured in 150 ED patients with abnormal NPT results, "ED" and 25 healthy subjects with normal NPT results. Bio-T and TSI,FTI. were calculated by the formula. The missed diagnosis rate, misdiagnosis rate and coincidence rate of cFT,TSI,FTI were calculated with cFT 鈮，

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