特异AT序列结合蛋白1和P504s在前列腺癌中的表达及临床意义

发布时间：2018-10-30 10:54

【摘要】：目的探讨P504s及特异AT序列结合蛋白1(SATB1)基因在前列腺癌的表达,及其在前列腺癌发生、发展中的作用。方法应用免疫组织化学染色检测P504s及SATB1蛋白在60例前列腺癌和30例前列腺增生症组织中的表达。结果 SATB1在前列腺癌组织中的表达阳性率(78.3%)较前列腺增生组织(0.0%)明显升高,差异有统计学意义(P0.05),SATB1的表达随着Gleason评分增加而升高(P0.05)。P504s在前列腺癌组织中的阳性表达率(95.0%)远高于前列腺增生症组(0.0%)(P0.05),但其在前列腺癌中的表达不会随着Gleason评分增加而升高(P0.05)。结论 P504s和SATB1在前列腺癌中的高表达,结合形态学综合分析,可能有助于提高前列腺癌的诊断及鉴别诊断,而SATB1蛋白在前列腺癌组织中的异常表达,提示可能与前列腺癌的发生、发展有关。
[Abstract]:Objective to investigate the expression of P504s and specific AT sequence-binding protein 1 (SATB1) gene in prostate cancer and its role in the pathogenesis and development of prostate cancer. Methods Immunohistochemical staining was used to detect the expression of P504s and SATB1 protein in 60 cases of prostate cancer and 30 cases of prostatic hyperplasia. Results the positive rate of SATB1 in prostate cancer tissues (78.3%) was significantly higher than that in prostatic hyperplasia tissues (0.00%), and the difference was statistically significant (P0.05). The expression of SATB1 increased with the increase of Gleason score (P0.05). The positive expression rate of P504s in prostate cancer (95.0%) was much higher than that in benign prostatic hyperplasia (0.00%) (P0.05). However, its expression in prostate cancer did not increase with the increase of Gleason score (P0.05). Conclusion the high expression of P504s and SATB1 in prostate cancer may be helpful to improve the diagnosis and differential diagnosis of prostate cancer, and the abnormal expression of SATB1 protein in prostate cancer may be associated with the occurrence of prostate cancer. Development is relevant.
【作者单位】：辽宁医学院病理学教研室;
【分类号】：R737.25

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