乌鲁木齐维吾尔族与汉族前列腺癌骨转移患者差异性研究

发布时间：2018-11-12 16:24

【摘要】：目的探究乌鲁木齐地区维吾尔族(维族)与汉族前列腺癌患者的骨转移特点。方法分别对75例维族和82例汉族前列腺癌患者采用SPECT进行全身核素骨显像,放射免疫法分析法测定血清骨钙素(BGP)水平,化学发光免疫分析法测血清白介素-6(IL-6)、游离前列腺特异抗原(F-PSA)和血清总前列腺特异抗原(T-PSA)水平及其比值(F/T)。结果骨显像阳性率维族为54.67%(75例),低于汉族76.83%(82例),血清骨钙素和IL-6水平维族均低于汉族,差异均有统计学意义(P0.05);血清F-PSA和T-PSA水平,两民族间差异无统计学意义(P0.05),但其比值(F/T)维族明显高于汉族(P0.05)。结论乌鲁木齐地区维族与汉族前列腺癌患者骨转移不同,汉族患者更容易发生骨转移,且肿瘤代谢指标活跃,累及范围较广,预后差。
[Abstract]:Objective to investigate the characteristics of bone metastasis in Uygur (Uygur) and Han patients with prostate cancer in Urumqi. Methods whole body radionuclide bone imaging was performed in 75 patients with prostate cancer of Uighur nationality and 82 patients with prostate cancer of Han nationality. Serum osteocalcin (BGP) levels were measured by radioimmunoassay and interleukin-6 (IL-6) was measured by chemiluminescence immunoassay. Free prostate specific antigen (F-PSA) and serum total prostate specific antigen (T-PSA) and their ratio (F / T). Results the positive rate of bone scintigraphy in Uygur nationality was 54.67% (75 cases), which was lower than that in the Han nationality 76.83% (82 cases). The levels of serum osteocalcin and IL-6 in Uygur nationality were significantly lower than those in the Han nationality (P0.05). There was no significant difference in serum F-PSA and T-PSA levels between the two nationalities (P0.05), but the ratio of F- / T was significantly higher in Uygur nationality than that in Han nationality (P0.05). Conclusion Bone metastasis is more likely to occur in Uygur and Han prostate cancer patients in Urumqi than in Han nationality, and the tumor metabolism index is active, the range of involvement is wide, and the prognosis is poor.
【作者单位】：新疆维吾尔自治区人民医院临床检验中心;乌鲁木齐市友谊医院心内三科;
【基金】：新疆维吾尔自治区人民医院院内项目(编号:20130116)
【分类号】：R737.25

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