肌层浸润性膀胱癌术中放疗的远期临床观察

发布时间：2018-11-21 21:07

【摘要】：目的：比较浸润性膀胱癌术中放疗，和传统的膀胱部分切除术与根治性全膀胱切除术的临床治疗效果。方法：回顾性分析114例原发性浸润性膀胱癌患者的临床资料，并根据治疗方式将其分为3组：部分切除组（A组，n=36），，术中放疗组（B组，n=35），以及根治组（C组，n=43）。分别对B组与A组，B组与C组两组患者的年龄，性别，肿瘤的临床分期，病理分级，手术时间、术中出血量、住院天数、术后肿瘤复发情况以及五年生存率进行统计分析。采用SPSS19.0统计软件进行处理，计量资料采用均数±标准差表示，计量资料采取t检验，计数资料采取X2检验，以P0.05为差异有统计学意义。结果：3组手术均成功完成。在A组与B组比较中，在性别、年龄、临床分期、病理分级、术中出血量，住院天数方面，差异无统计学意义（P0.05），在手术时间，肿瘤复发及五年生存率方面，差异有统计学意义（P0.05）；在C组与B组中，在性别、年龄、临床分期、病理分级、肿瘤复发及五年生存率方面，差异无统计学意义（P0.05），在手术时间，术中出血量，住院天数方面，差异有统计学意义（P0.05）。结论：本实验术中放疗组治疗浸润性膀胱癌的肿瘤复发率及五年生存率均与根治组相近，明显优于膀胱部分切除组，而手术创伤及术后恢复情况却与膀胱部分切除术相似，是浸润性膀胱癌是除根治术外又一项可行的治疗方式。
[Abstract]:Objective: to compare the clinical effects of intraoperative radiotherapy for invasive bladder cancer and traditional partial cystectomy and radical total cystectomy. Methods: the clinical data of 114 patients with primary invasive bladder cancer were retrospectively analyzed and divided into 3 groups according to the treatment methods: partial resection group (group A, n = 36), intraoperative radiotherapy group (group B, n = 35) and radical resection group (group C, n = 43). The age, sex, clinical stage, pathological grade, operative time, intraoperative bleeding volume, hospital stay, recurrence of tumor and 5-year survival rate were statistically analyzed in group B and group A, group B and group C respectively. SPSS19.0 statistical software was used to process the measurement data with mean 卤standard deviation, measurement data with t test, count data with X2 test, with P0.05 as the difference was statistically significant. Results: all the 3 groups were successfully completed. There was no significant difference between group A and group B in sex, age, clinical stage, pathological grade, intraoperative bleeding volume and length of hospitalization (P0.05), but there was no significant difference in operative time, tumor recurrence and 5-year survival rate. The difference was statistically significant (P0.05). In group C and group B, there was no significant difference in sex, age, clinical stage, pathological grade, tumor recurrence and 5-year survival rate (P0.05). The difference was statistically significant (P0.05). Conclusion: the tumor recurrence rate and 5-year survival rate in the intraoperative radiotherapy group were similar to those in the radical resection group, and were significantly superior to those in the partial cystectomy group, but the surgical trauma and postoperative recovery were similar to those in the cystectomy group. Invasive bladder cancer is a feasible treatment in addition to radical resection.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.14

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