2010-2012年青岛大学医学院附属医院泌尿生殖道支原体感染及耐药性分析

发布时间：2018-11-24 20:55

【摘要】：目的探讨泌尿生殖道支原体感染患者支原体培养情况并分析其耐药性变化,为临床上合理使用抗生素提供参考依据。方法对2010年1月-2012年12月青医附院门诊收治的1236例怀疑泌尿生殖道支原体感染患者进行支原体培养与药敏试验,并对结果进行分析。结果1236例支原体属培养结果中阳性316例(25.57%),其中解脲脲原体(Uu)245例(19.82%),人型支原体(Mh)10例(0.81%),Uu+Mh混合感染61例(4.94%)；在女性患者中Uu和Uu+Mh阳性率分别为27.05%、6.54%,均显著高于男性(Uu7.46%、Uu+Mh2.19%,P0.05)。Uu对氧氟沙星、罗红霉素、司帕沙星耐药率较高,分别为26.53%、17.96%、15.92%,Uu+Mh只对强力霉素和美满霉素耐药性较低；3年中支原体对抗生素耐药性变化不一,2011、2012年Uu耐药率较2010年有所下降,Uu+Mh耐药性有逐渐升高趋势。结论泌尿生殖道支原体感染培养阳性率在女性中明显高于男性。其对常见抗生素耐药率较高,临床上应行支原体培养+药敏试验,合理使用抗生素。
[Abstract]:Objective to investigate the mycoplasma culture in patients with urogenital tract infection and to analyze the change of drug resistance in order to provide reference for the rational use of antibiotics in clinic. Methods from January 2010 to December 2012, 1236 patients with suspected urogenital tract mycoplasma infection were examined by mycoplasma culture and drug sensitivity test, and the results were analyzed. Results 1236 cases of mycoplasma were positive in 1236 cases (25.57%), including (Uu) of Ureaplasma Urealyticum (19.82%) and (Mh) of human type (0.81%). 61 cases (4.94%) were co-infected with Ureaplasma Urealyticum and Mycoplasma hominis (0.81%). The positive rates of Uu and Uu Mh in female patients were 27.05 and 6.54, respectively, which were significantly higher than those in male patients (Uu7.46%,Uu Mh2.19%,P0.05). Uu resistance rate to ofloxacin, roxithromycin and sparfloxacin was higher than that of male patients. The drug resistance of Mh to doxycycline and minocycline was lower than that of Mh. The drug resistance of mycoplasma to antibiotics varied in three years. The resistance rate of Uu in 2012 was lower than that in 2010, and the drug resistance of, Uu Mh increased gradually in 2011 and 2012. Conclusion the positive rate of mycoplasma infection in the genitourinary tract was significantly higher in women than in men. The rate of drug resistance to common antibiotics was high, and the drug sensitivity test of mycoplasma culture should be carried out in clinic, and antibiotics should be used rationally.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R691.3

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