导尿管相关尿路感染的病原菌特点与耐药性分析

发布时间：2018-12-11 04:07

【摘要】：目的了解住院患者导尿管相关尿路病原菌分布及其耐药性,为医院泌尿系感染的防控提供参考。方法回顾性调查住院接受尿道插管留置导尿患者尿路感染发生情况,分析病原菌分布和药敏试验结果。结果共发现876例尿道插管住院患者中发现532例相关尿路感染患者例,感染发生率为60.73%。从感染患者送检标本中共检出病原菌532株,其中包括革兰阴性杆菌351株、革兰阳性球菌116株和真菌65株,构成比分别为65.98%、21.81%和12.22%。居前4位的病原菌依次为大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌和屎肠球菌。革兰阴性杆菌对喹诺酮耐药率较高,对亚胺培南、头孢派酮/舒巴坦耐等较敏感;革兰阳性球菌耐药率普遍较高,真菌耐药率均比较低。结论接受尿管插管住院患者相关尿路感染发病率高,病原菌以革兰阴性菌为主,耐药谱广,应加强耐药菌监测,依据药敏试验结果合理选用抗菌药物。
[Abstract]:Objective to investigate the distribution and drug resistance of urinary tract pathogens in hospitalized patients, and to provide reference for the prevention and control of urinary tract infection in hospital. Methods the incidence of urinary tract infection in patients with urethral catheterization was investigated retrospectively. The distribution of pathogens and the results of drug sensitivity test were analyzed. Results 532 cases of urinary tract infection were found out of 876 inpatients with urethral intubation, the incidence of infection was 60.73. A total of 532 strains of pathogenic bacteria including 351 Gram-negative bacilli, 116 Gram-positive cocci and 65 fungi were detected from infected patients. The composition ratios were 65.9821.81% and 12.2221%, respectively. The leading pathogens were Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae and Enterococcus faecium. Gram-negative bacilli showed higher resistance to quinolones, more sensitive to imipenem and cefazone / sulbactam, and Gram-positive cocci showed higher resistance to quinolones and lower rates of fungal resistance. Conclusion the incidence of urinary tract infection in inpatients with urinary tube intubation is high, the main pathogens are Gram-negative bacteria, and the spectrum of drug resistance is wide. The surveillance of drug-resistant bacteria should be strengthened, and antibiotics should be reasonably selected according to the results of drug sensitivity test.
【作者单位】：北京市第六医院;北京市朝阳医院;
【分类号】：R691.3

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