甲状腺激素阴茎神经电生理诱发早泄的作用机制

发布时间：2018-12-21 21:09

【摘要】：目的甲状腺激素功能改变影响男性性功能的具体生理机制尚不明确。文中旨在探讨甲状腺激素通过影响阴茎神经电生理而诱发早泄的作用。方法回顾性分析2015年10月至2016年12月于南京总医院男科门诊就诊,并诊断为继发性早泄患者52例(早泄组),同期来院进行体检的24名健康男性作为对照组。所有被纳入者经过男科体检及甲状腺激素检验。此外,继发性早泄患者经过阴茎交感皮肤反应(PSSR)检查,根据PSSR潜伏期长短,将早泄组分为PSSR正常组及异常组。结果早泄组总四碘甲状腺原氨酸(TT4)水平显著高于对照组,差异有统计学意义[(92.68±11.56)nmol/L vs(102.81±18.37)nmol/L,P=0.018)];与PSSR正常组相比,异常组的TT4及游离四碘甲状腺原氨酸(FT4)水平均显著增高,分别为[(95.72±12.42)nmol/L vs(113.28±20.89)nmol/L,P0.01]和[(10.81±1.63)nmol/L vs(12.02±0.88)nmol/L,P=0.003]。FT4与PSSR潜伏期呈负相关(r=-0.363,P=0.008),与PEDT呈正相关(r=0.455,P=0.001)。结论继发性早泄患者异常的PSSR可能与甲状腺激素的水平升高相关;调节伴有异常PSSR的继发性早泄患者的甲状腺激素水平有利于改善其早泄症状。
[Abstract]:Objective the effect of thyroid hormone on male sexual function is unclear. The purpose of this paper is to investigate the effect of thyroid hormone on premature ejaculation induced by the effect of penile electrophysiology. Methods from October 2015 to December 2016, 52 patients (premature ejaculation group) were diagnosed as secondary premature ejaculation patients, and 24 healthy men who came to Nanjing General Hospital for physical examination as control group were analyzed retrospectively from October 2015 to December 2016. All participants underwent male medical examination and thyroid hormone test. In addition, the patients with secondary premature ejaculation underwent (PSSR) examination of penile sympathetic skin reaction. According to the PSSR latency, the premature ejaculation group was divided into normal PSSR group and abnormal group. Results the level of total tetraiodothyronine (TT4) in premature ejaculation group was significantly higher than that in control group [(92.68 卤11.56) nmol/L vs (102.81 卤18.37) nmol/L,P=0.018]. The levels of TT4 and free tetraiodothyronine (FT4) in abnormal group were significantly higher than those in normal PSSR group, and were [(95.72 卤12.42) nmol/L vs (113.28 卤20.89) nmol/L,], respectively. P0.01] and [(10.81 卤1.63) nmol/L vs (12.02 卤0.88) nmol/L,P=0.003] .There was a negative correlation between FT4 and the latent period of PSSR (r = -0.363) and a positive correlation with PEDT (r = 0.455P ~ (0. 001). Conclusion abnormal PSSR in patients with secondary premature ejaculation may be related to the increase of thyroid hormone level, and regulating thyroid hormone level in patients with secondary premature ejaculation with abnormal PSSR is helpful to improve the symptoms of premature ejaculation.
【作者单位】：南方医科大学金陵医院(南京军区南京总医院)生殖医学中心;
【基金】：国家重大基础研究发展计划(2013CB945200)
【分类号】：R698

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