停用免疫抑制药对肾移植肺部感染患者人肾长期存活的影响

发布时间：2018-12-30 21:52

【摘要】：目的:探讨停用免疫抑制药对肾移植受体及移植肾长期生存的影响。方法:选取2005年12月至2014年8月在中南大学湘雅医院器官移植中心接受肾移植手术后出现肺部感染的患者共104例,其中50例患者在肺部感染治疗期间停用免疫抑制药,作为停药组,余54例作为对照组。比较两组间受者以及肾5年累积生存率及感染期间生化指标的变化情况。结果:停药组的受体5年累积生存率明显低于对照组[(69.8±7.0)%对比(94.2±3.2)%,P=0.001],但移植肾生存率两组间差异无统计学意义[(81.7±6.6)%对比(90.9±4.3)%,P=0.113]。肺部感染康复后,停药组受体的长期生存率与对照组相比差异无统计学意义(P=0.979)。结论:肺部感染严重危害肾移植受体的生存;停用免疫抑制药对于肾移植术后严重肺部感染患者而言并不影响患者和移植肾的长期存活。
[Abstract]:Objective: to investigate the effects of discontinuation of immunosuppressive drugs on the long-term survival of renal transplant recipients and transplanted kidneys. Methods: from December 2005 to August 2014, 104 patients with pulmonary infection were selected from organ transplantation center of Xiangya Hospital of Central South University, and 50 of them stopped using immunosuppressive drugs during the treatment of lung infection. The rest 54 cases were taken as control group. The 5-year cumulative survival rate of recipient and kidney and the changes of biochemical indexes during infection were compared between the two groups. Results: the 5-year cumulative survival rate in the withdrawal group was significantly lower than that in the control group [(69.8 卤7.0)% vs (94.2 卤3.2)%, P < 0.001]. However, there was no significant difference in survival rate between the two groups [(81.7 卤6.6)% vs (90.9 卤4.3)%, P < 0.113]. There was no significant difference in long-term survival rate between the withdrawal group and the control group after the recovery of pulmonary infection (P0. 979). Conclusion: lung infection is a serious threat to the survival of renal transplant recipients, and discontinuation of immunosuppressive drugs does not affect the long-term survival of patients with severe pulmonary infection after renal transplantation.
【作者单位】：中南大学湘雅医院器官移植中心;
【基金】：国家自然科学基金青年基金(30801386) 湖南省科技计划重点项目(2013FJ2007)~~
【分类号】：R699.2

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