真空负压勃起装置联合PDE5抑制剂治疗勃起功能障碍患者的疗效和安全性Meta分析

发布时间：2018-12-31 16:18

【摘要】：目的观察真空负压勃起装置(VED)联合PDE5抑制剂治疗男性勃起功能障碍(ED)的疗效。方法检索Cochrane Library、Medline、中国生物医学文献数据库、中国知网、维普以及万方数据库。检索时间从建库至2016年12月,纳入VED联合PDE5抑制剂治疗ED的随机对照治疗(RCTs)并进行方法学的质量评估。文献数据采用Rev Man5.3软件进行统计学分析,并根据异质性进行敏感性分析和发表偏倚风险评估。结果 10篇RCT文献纳入本项研究,累计病例1 327例。Meta分析结果显示:联合治疗组在改善患者满意度方面[RR=1.34,95%CI(1.17,1.54),P0.01]具有明显优势且差异具有统计学意义,并且单独应用VED亦可改善患者满意度[RR=1.27,95%CI(1.11,1.46),P0.01]。联合治疗组可明显提高患者的IIEF评分[WMD=4.52,95%CI(2.54,6.50),P0.01],而在单独应用VED提高患者IIEF评分方面[WMD=-2.07,95%CI(-6.17,2.03),P0.05],与对照组相比差异并无统计学意义。研究报道VED使用过程中未发生严重的不良反应,患者耐受性好。结论 VED联合PDE5抑制剂可更有效地改善ED患者的满意度,并显著提高IIEF-5评分,是治疗男性ED的有效方式,但仍需更多的大样本、高质量、多中心的随机对照实验加以远期验证。
[Abstract]:Objective to observe the efficacy of (VED) combined with PDE5 inhibitor in the treatment of male erectile dysfunction (ED). Methods Cochrane Library,Medline, Chinese Biomedical Literature Database, China knowledge Network, Weip and Wanfang databases were searched. The retrieval time was from the establishment of the library to December 2016. The randomized controlled therapy (RCTs) with VED combined with PDE5 inhibitor for ED was included and the quality of the methodology was evaluated. The literature data were statistically analyzed by Rev Man5.3 software, sensitivity analysis and publication bias risk assessment according to heterogeneity. Results Ten articles of RCT were included in this study, the cumulative cases were 1 327 cases. The results of Meta analysis showed that the combined treatment group could improve the satisfaction of patients [RR=1.34,95%CI (1.17 卤1.54)], P0.01 has obvious advantages and the difference is statistically significant, and the use of VED alone can also improve patient satisfaction [RR=1.27,95%CI (1.111.46), P0.01]. The combined treatment group could significantly improve the IIEF score of the patients [WMD=4.52,95%CI (2.54 卤6.50), P0.01], while the VED alone could improve the IIEF score of the patients [WMD=-2.07,95%CI (-6.17 卤2.03), P0.05]. There was no significant difference compared with the control group. The study reported that no serious adverse reactions occurred during the use of VED and that patients had good tolerance. Conclusion VED combined with PDE5 inhibitor can improve the satisfaction of ED patients more effectively and improve IIEF-5 score significantly. It is an effective way to treat male ED, but it still needs more large samples and high quality. A multicenter randomized controlled trial was used for long-term validation.
【作者单位】：国家卫生和计划生育委员会男性生殖健康重点实验室国家卫生计生委科学技术研究所;北京协和医学院研究生院;
【分类号】：R698.1

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