补肾活血法联合糖皮质激素治疗原发性肾病综合征的临床研究

发布时间：2019-01-05 11:58

【摘要】：目的：通过补肾活血法联合糖皮质激素治疗原发性肾病综合征的临床研究，初步评价补肾活血法联合糖皮质激素的中西医结合治疗方案在增强疗效、减轻毒副反应方面的作用。 方法：本研究收集原发性肾病综合征符合中医辨证肾虚血瘀证患者60例，分为试验组30例，对照组30例。对照组予免疫抑制、降蛋白尿等西医基础治疗，试验组在西医基础治疗上加用益肾活血汤，疗程为3个月。观察临床症状、体征及实验室检查指标的变化，并对症状及体征进行量化评分；观察激素引起的副作用及减量过程中出现的反跳复发现象，，作出疗效评价。 结果：试验组在改善临床症状及检验指标方面均优于对照组；试验组激素副作用的发生率总体上低于对照组。试验组能够提高临床缓解率，改善临床症状；降低蛋白尿的排泄，升高血白蛋白水平，降低D二聚体，改善高凝状态；减少激素的副作用及激素减药过程中疾病的反跳和复发。 结论：补肾活血法结合糖皮质激素治疗原发性肾病综合征具有提高激素疗效、减轻激素毒副反应的作用，中西医联合治疗方案值得进一步研究推广应用。
[Abstract]:Objective: to evaluate the effect of Bushen Huoxue method combined with glucocorticoid in the treatment of primary nephrotic syndrome. Methods: 60 patients with primary nephrotic syndrome were divided into experimental group (n = 30) and control group (n = 30). The control group was treated with basic western medicine such as immunosuppression and proteinuria. The experimental group was treated with Yishen Huoxue decoction for 3 months. The changes of clinical symptoms, physical signs and laboratory indicators were observed, and the scores of symptoms and signs were quantified, and the side effects caused by hormones and the phenomenon of rebound recurrence in the course of reduction were observed, and the curative effect was evaluated. Results: the experimental group was superior to the control group in improving clinical symptoms and testing indexes, and the incidence of hormone side effects in the trial group was lower than that in the control group. The experimental group can increase the clinical remission rate and improve the clinical symptoms, reduce the excretion of proteinuria, raise the level of serum albumin, reduce the D-dimer, improve the hypercoagulability, reduce the side effects of hormones, and reduce the rebound and recurrence of diseases in the course of hormone reduction. Conclusion: the therapy of tonifying kidney and activating blood circulation combined with glucocorticoid therapy can improve the effect of hormone and reduce the toxic and side effects of hormone. The combination of traditional Chinese and western medicine is worthy of further study and application.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R692

【参考文献】

相关期刊论文 前10条

1 郑夏珍;中药对激素治疗肾病综合征的干预作用[J];安徽中医临床杂志;2003年06期

2 周硕果;;浅谈肾病综合征的中医辨治[J];中医药临床杂志;2005年06期

3 李笑春;戴敏;陈鹏;;丹皮酚对高脂血清诱导的大鼠主动脉内皮细胞损伤的保护作用及其黏附功能的影响[J];安徽中医学院学报;2010年01期

4 何永婷;朱贺年;;车前子的研究进展[J];北方药学;2011年01期

5 付平,周莉,赵明生,李雪梅;灯盏细辛对原发性肾病综合征高凝状态和尿蛋白的影响[J];广东医学;2003年10期

6 陈朝霞;;中西医结合治疗肾病综合征36例疗效观察[J];甘肃中医;2006年11期

7 黄南龙;张碧玉;;简述黄芪的药理作用与临床应用[J];海峡药学;2009年01期

8 沈舒;王琼;李友宾;;牛膝的化学成分和药理作用研究进展[J];海峡药学;2011年11期

9 孙中诚,董尚朴;肾病综合征的中医病因病机及辨证要点[J];河北中医;2003年03期

10 汪贤聪,郭志义,甘喜;中西医结合治疗成人原发性肾病综合征42例[J];湖北中医杂志;2001年04期

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