NGAL在急性肾损伤早期临床诊断价值的系统评价

发布时间：2019-01-11 13:20

【摘要】：目的：采用系统评价方法评估中性粒细胞明胶酶相关脂质运载蛋白（NGAL）在急性肾损伤早期的临床诊断价值。方法：计算机电子检索Pubmed、Cochrane、EMBASE、CNKI、万方、维普等数据库中与NGAL相关的文献，根据纳入排除标准筛选文献，，提取纳入研究特征数据。采用QUADAS 2质量评价工具进行纳入研究的文献质量评价。利用Meta Disc1.4软件，根据异质性特点选择相应模型，进行诊断统计量合并。结果：初筛到5511篇文献，严格根据纳入排除标准，最终纳入35篇文献，共纳入研究对象8941例，其中AKI组患者2210例。Meta分析结果显示尿NGAL与血NGAL的合并敏感度、特异度、综合受试者工作特征曲线下面积分别为0.73（95%CI:0.71 0.76）、0.73（95%CI:0.72 0.74）、0.8658（SE:0.0201）以及0.80（95%CI:0.77 0.83）、0.76（95%CI:0.74 0.78）、0.8977（SE:0.0214）。结论：血、尿NGAL对于患者AKI的发生预测，有较好的敏感度和特异度，对患者AKI的早期诊断有重要意义。
[Abstract]:Objective: to evaluate the clinical value of neutrophil gelatinase-associated lipid carrier protein (NGAL) in the early stage of acute renal injury. Methods: the literatures related to NGAL in Pubmed,Cochrane,EMBASE,CNKI, Wanfang and Weip databases were searched by computer, and the data were extracted according to the inclusion exclusion criteria. The literature quality was evaluated by QUADAS 2 quality evaluation tool. By using Meta / Disc1.4 software, the corresponding models were selected according to the characteristics of heterogeneity, and the diagnostic statistics were merged. Results: from the first screening to 5511 articles, strictly according to the exclusion criteria, 35 articles were included in the study. A total of 8941 subjects were included in the study, including 2210 patients in the AKI group. The results of Meta analysis showed the combined sensitivity and specificity of urinary NGAL and blood NGAL. The area under the operating characteristic curve was 0.73 (95%CI:0.71 0.76), 0.73 (95%CI:0.72 0.74), 0.8658 (SE:0.0201) and 0.80 (95%CI:0.77 0.83), respectively. 0.76 (95%CI:0.74 0.78), 0.8977 (SE:0.0214). Conclusion: NGAL in blood and urine has good sensitivity and specificity in predicting the occurrence of AKI in patients. It is important for the early diagnosis of AKI in patients.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R692

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