尿道多重耐药菌定植与导尿管相关尿路感染关联性的巢式病例对照研究

发布时间：2019-02-16 01:18

【摘要】：目的验证重症监护病房(ICU)患者导尿管相关性尿路感染(CAUTI)与尿道多重耐药菌(MDROs)定植的关系。方法采用巢式病例对照研究法。调查2015年6月1日-2016年12月31日某医院ICU留置导尿的所有患者CAUTI发生情况,比较病例组和对照组间尿道MDROS定植率差异;分析CAUTI主要危险因素及其与MDROs的相关性。结果纳入队列研究的CAUTI病例组共176例,对照组共336例。与对照组相比,病例组的MDROS定植率增高明显(χ2=10.831,P0.05),总住院时间和入住ICU时间也较长(Z=-10.102和-11.298,P值均0.05)。MDROs定植与CAUTI风险呈正相关(OR=2.404,P0.05)。与MDROs阴性患者相比,CAUTI病例组中阳性感染患者的抗菌药物使用时间较长(Z=-4.333,P0.05)。结论 ICU留置导尿患者中尿道MDROs定植CAUTI发病风险显著升高,抗菌药物选择难度较大。
[Abstract]:Objective to investigate the relationship between urinary catheter associated urinary tract infection (CAUTI) and urethral multidrug resistance bacteria (MDROs) colonization in (ICU) patients in intensive care unit (ICU). Methods nested case-control study was used. To investigate the incidence of CAUTI in all patients with ICU catheterization in a hospital from June 1, 2015 to December 31, 2016, to compare the urethral MDROS colonization rate between the case group and the control group, and to analyze the main risk factors of CAUTI and its correlation with MDROs. Results 176 cases of CAUTI and 336 cases of control group were enrolled in cohort study. The colonization rate of MDROS in the case group was significantly higher than that in the control group (蠂 2, 10.831, P 0.05), and the total hospitalization time and the time to stay in ICU were also longer (ZTX -10.102 and -11.298, P < 0.05). P values were 0. 05). MDROs positive correlation with CAUTI risk (OR=2.404,P0.05). Compared with the patients with negative MDROs, the patients with positive infection in CAUTI group had longer time of using antibiotics (P 0.05). Conclusion the risk of urethral MDROs colonization CAUTI in patients with ICU indwelling catheterization is significantly increased, and the choice of antimicrobial agents is difficult.
【作者单位】：贵州医科大学第三附属医院;贵州省人民医院;
【基金】：贵州省科技厅联合项目(黔科合LH字[2014]7162号) 贵州省黔南州社会发展科技项目(黔南科合社字[2013]20号)
【分类号】：R691.3

【相似文献】