补肾活血法组方联合西药治疗肾病综合征60例疗效观察

发布时间：2019-03-15 15:35

【摘要】：目的观察补肾活血法组方联合西药治疗肾病综合征(NS)的临床疗效。方法将120例NS患者随机分为对照组60例和治疗组60例。对照组采用西医常规治疗方法及对症支持治疗:强的松1 mg/(kg·d),顿服,8周后逐渐减量,每周减5 mg;雷公藤多苷10 mg,每天3次。治疗组在对照组基础上加用补肾活血法组方。两组均治疗3个月后观察临床疗效,于治疗前后采用双缩尿法检测24小时尿蛋白定量;溴甲酚绿检测法检测血白蛋白(ALB)水平;酶法检测胆固醇(TC)和甘油三酯(TG)水平。结果治疗组临床疗效总有效率为90%,对照组为65%,治疗组明显优于对照组(P0.05)。与治疗前比较,两组治疗后24 h尿蛋白定量显著下降、血ALB显著升高(P0.01);治疗组24h尿蛋白定量下降程度优于对照组,血ALB升高程度亦优于对照组(P0.01)。两组治疗后TG、TC水平显著下降(P0.01),且治疗组TC下降程度优于对照组(P0.01)。结论补肾活血法组方联合西药治疗NS能显著提高临床疗效,降低尿蛋白及血脂。
[Abstract]:Objective to observe the clinical effect of Bushen Huoxue recipe combined with western medicine in the treatment of nephrotic syndrome (NS). Methods 120 patients with NS were randomly divided into control group (n = 60) and treatment group (n = 60). The control group was treated with conventional western medicine and symptomatic support: prednisone 1 mg/ (kg 路d),) was gradually reduced after 8 weeks, and 5 mg; polyglycoside of Tripterygium wilfordii was reduced 3 times a week 3 times a week. On the basis of the control group, the treatment group added the prescription of tonifying the kidney and promoting blood circulation. The clinical efficacy was observed after 3 months of treatment in both groups. Before and after treatment, 24-hour urinary protein was measured by diuresis method, (ALB) level of serum albumin was detected by bromocresol green assay, and the serum albumin level was measured by bromocresol green assay. The levels of cholesterol (TC) and triglyceride (TG) were measured by enzyme method. Results the total effective rate was 90% in the treatment group and 65% in the control group, and the treatment group was significantly better than the control group (P0.05). Compared with the pre-treatment group, the 24-hour urinary protein quantity decreased significantly and the blood ALB increased significantly in the two groups after treatment (P0.01), and the level of 24-hour urinary protein in the treatment group was better than that in the control group (P0.01). After treatment, the level of TG,TC in the two groups decreased significantly (P0.01), and the level of TC in the treatment group was better than that in the control group (P0.01). Conclusion the prescription of tonifying kidney and activating blood circulation combined with western medicine can significantly improve the clinical efficacy and reduce the urinary protein and blood lipid in the treatment of NS.
【作者单位】：天津市滨海新区汉沽中医医院;天津市公安医院;
【分类号】：R692

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