HOLRBT与TURBT治疗非肌层浸润性膀胱癌的研究进展

发布时间：2019-03-23 17:21

【摘要】：膀胱肿瘤是泌尿系统中最常见的肿瘤，在世界范围内也是一种常见恶性肿瘤，在美国的发病率居男性第四位，女性的第九位。在我国，男性膀胱癌的发病率位居全身恶性肿瘤的第八位，女性排第十二位以后，男性的发病率为女性的3-4倍。城镇居民的膀胱癌发病率明显高于农村居民。膀胱恶性肿瘤按来源可分为：尿路上皮癌90%；鳞状细胞癌1～7%；腺癌2%。在尿路上皮癌中，75～85%是非肌层浸润性膀胱癌[4-8]。根据国际抗癌协会2009年第七版TNM分期法，将原位癌（Tis),非浸润性乳头状癌(Ta),肿瘤侵及上皮下结缔组织(T1)划分为非肌层浸润性膀胱癌，，由于非肌层浸润性膀胱癌又具有易复发的特性，Ta期患者3年内复发率约50%~70%，约5%可发展为浸润性癌，而T1期3年内约有80%的患者复发，发展为浸润性癌的概率则高达50%，所以，如何更好的治疗非浸润性膀胱癌一直以来都是广大医务工作者的一项重要课题。本文通过对比的方法对经尿道膀胱肿瘤电切术（TURBT）及经尿道膀胱肿瘤钬激光切除术（HOLRBT）在适应症、工作原理、技术方法、疗效及术后并发症等方面的研究进展进行综述，分析二者在临床应用上的优劣势，并提出前景展望。
[Abstract]:Bladder tumor is the most common tumor in the urinary system. It is also a common malignant tumor in the world. The incidence of bladder cancer in the United States is the fourth in men and the ninth in women. In China, the incidence of bladder cancer in men ranks eighth in malignant tumors of the whole body, and after ranking 12th in women, the incidence of bladder cancer in men is 4 times higher than that in women. The incidence of bladder cancer in urban residents was significantly higher than that in rural residents. Malignant tumors of the bladder can be classified into: urothelial carcinoma 90%; squamous cell carcinoma 1-7%; Adenocarcinoma 2%. In urothelial carcinoma, 75 / 85% were non-muscular invasive bladder cancer [4 / 8]. According to the TNM staging method of the seventh edition of the International Anti-Cancer Association in 2009, (Ta), tumor invading subepithelial connective tissue (T1) of carcinoma in situ is classified as non-muscular invasive bladder cancer. As non-muscular invasive bladder cancer is also prone to recurrence, the recurrence rate of Ta patients within 3 years is about 50% and 70%, and about 5% can develop into invasive carcinoma, while in T1 stage, 80% of the patients recur within 3 years, and the recurrence rate of non-invasive bladder cancer is about 50% and 70% within 3 years. The probability of developing invasive cancer is as high as 50%. Therefore, how to better treat non-invasive bladder cancer has always been an important topic for medical workers. In this paper, the research progress of transurethral resection of bladder tumor (TURBT) and transurethral resection of bladder tumor (HOLRBT) in the aspects of indication, working principle, technical method, curative effect and postoperative complications were reviewed. The advantages and disadvantages of the two methods in clinical application were analyzed, and the prospect was put forward.
【学位授予单位】：蚌埠医学院
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R737.14

【参考文献】