α-硫辛酸胶囊联合枸橼酸他莫昔芬片治疗少弱精子症的疗效观察

发布时间：2019-04-04 13:18

【摘要】：目的:观察α-硫辛酸胶囊联合枸橼酸他莫昔芬片对少弱精子症患者的疗效。方法:选择2016年6~11月就诊的60例少弱精子症患者,将其随机分为2组,每组30例。治疗组给予α-硫辛酸胶囊(0.6 g,1次/d)联合枸橼酸他莫昔芬片(20 mg,1次/d)口服治疗,对照组给予左卡尼汀口服液(1 g,2次/d)联合枸橼酸他莫昔芬片(20 mg,1次/d)口服治疗,治疗前及治疗后3个月检测所有病例精液参数及精液氧化应激生物标志物,包括丙二醛(MDA),总抗氧能力(TAC)水平,同时了解配偶妊娠率及不良反应发生情况。结果:57例患者完成了全部治疗,包括治疗组28例,对照组29例。治疗组治疗前、后精液量分别为(2.50±0.71)ml、(3.37±0.70)ml,精子浓度(12.00±1.65)×10~6/ml、(19.34±2.04)×10~6/ml,前向运动精子百分率(18.01±3.01)%、(35.41±6.49)%,精浆TAC(9.83±1.02)U/ml、(12.25±1.11)U/ml,MDA(14.96±2.76)nmol/ml、(10.04±1.04)nmol/ml;对照组治疗前、后精液量分别为(2.76±0.67)ml、(3.36±0.93)ml,精子浓度(11.47±1.10)×10~6/ml、(17.77±3.56)×10~6/ml,前向运动精子百分率(19.22±1.41)%、(36.01±5.22)%、精浆TAC(9.84±0.90)U/ml、(11.14±0.84)U/ml,MDA(14.66±2.75)nmol/ml、(10.14±1.01)nmol/ml,上述各指标两组治疗后均较治疗前有显著改善(P0.05),精浆TAC改善方面治疗组优于对照组(P0.05),其余指标两组之间差异无统计学意义(P0.05),两组正常形态精子百分率治疗前后无统计学差异(P0.05)。治疗3个月后配偶妊娠,治疗组3例(10.7%),对照组1例(3.45%),两组比较差异无统计学意义(P0.05),治疗期间所有患者均未见明显不良反应。结论:α-硫辛酸胶囊联合枸橼酸他莫昔芬片可明显改善精浆氧化应激损伤,进而改善少弱精子症患者的精液质量。
[Abstract]:Objective: to observe the therapeutic effect of 伪-lipoic acid capsule combined with tamoxifen citrate tablets on oligoasthenospermia. Methods: 60 patients with oligozoospermia from June to November 2016 were randomly divided into two groups with 30 cases in each group. The treatment group was treated with 伪-lipoic acid capsule (0.6g, once a day) combined with tamoxifen citrate tablet (20 mg,1 / d), while the control group was treated with levocarnitine oral liquid (1g, 1g). (2 / d) combined with tamoxifen citrate (20 mg,1 / d) oral treatment. Semen parameters and biomarkers of oxidative stress, including malondialdehyde (MDA), were measured before and 3 months after treatment. The level of total antioxidant capacity (TAC), pregnancy rate and adverse reactions were also investigated. Results: 57 patients completed all treatment, including 28 cases in the treatment group and 29 cases in the control group. Before treatment, the sperm volume of the treatment group was (2.50 卤0.71) ml, (3.37 卤0.70) ml, sperm concentration (12.00 卤1.65) 脳 10 ~ (6) mmol / ml, (19.34 卤2.04) 脳 10 ~ (6) mmol / ml, and the percentage of forward motility sperm was (18.01 卤3.01)%. (35.41 卤6.49)%, seminal plasma TAC (9.83 卤1.02) U / ml, (12.25 卤1.11) U / ml, (14.96 卤2.76) nmol/ml, (10.04 卤1.04) nmol/ml; Before the treatment, the sperm volume of the control group was (2.76 卤0.67) ml, (3.36 卤0.93) ml, sperm concentration (11.47 卤1.10) 脳 10 脳 10 ~ (6) mmol / ml, (17.77 卤3.56) 脳 10 脳 10 ~ (6) mmol / ml, and the percentage of forward motility sperm was (19.22 卤1.41)%. (36.01 卤5.22)%, seminal plasma TAC (9.84 卤0.90) U / ml, (11.14 卤0.84) U / ml, (14.66 卤2.75) nmol/ml, (10.14 卤1.01) nmol/ml, The above indexes were significantly improved in the two groups after treatment (P0.05), and the improvement of seminal plasma TAC in the treatment group was better than that in the control group (P0.05), while there was no significant difference between the other two groups (P0.05). There was no statistical difference in the percentage of normal morphology sperm between the two groups before and after treatment (P0.05). There were 3 cases (10.7%) in the treatment group and 1 case (3.45%) in the control group after 3 months of treatment. There was no significant difference between the two groups (P0.05). No obvious adverse reaction was observed in all the patients during the treatment. Conclusion: 伪-lipoic acid capsule combined with tamoxifen citrate tablets can significantly improve the damage of seminal plasma oxidative stress, and then improve the semen quality of oligoasthenospermia patients.
【作者单位】：河北医科大学第二医院泌尿外科;
【分类号】：R698.2

【相似文献】