OPG、MIG尿液中的表达与移植肾损伤的临床观察

发布时间：2019-04-12 17:04

【摘要】：目的:通过检测肾移植术后尿液中骨保护素(OPG)、γ干扰素诱导单核因子(MIG)水平,监测移植肾损伤情况。方法:选择2012年3月至2013年1月间器官移植科接受同种异体肾移植的40例尿毒症患者,根据肾移植术后肾功能恢复情况分组,20例发生移植肾功能损害的患者入损伤组,20例肾移植术后肾功能恢复正常的患者入非损伤组,健康人20例为对照组。术后按规定时间留取晨尿检测术后0、1、2、3、5、7 d的OPG和MIG水平。结果:OPG和MIG的检测值,损伤组(79±13)ng/L,(514.3±79.8)ng/L均明显高于非损伤组(3.6±1.89)ng/L,(86.8±19.36)ng/L,与对照组比较,差异有统计学意义(P0.01);非损伤组(86.8±19.36)ng/L与对照组比较(13.2±5.33)ng/L,MIG差异有统计学意义(P0.05),而OPG两组的差异无统计学意义(P0.05)。结论:OPG、MIG在肾移植术后尿液中不同程度的表达,作为生物标志物已显示出其潜在的价值,亦有可能成为评估移植肾损伤的相关实验室指标。
[Abstract]:Aim: to detect the level of monocyte factor (MIG) induced by osteoprotegerin (OPG), 纬 interferon in urine after renal transplantation and to monitor the renal allograft injury. Methods: from March 2012 to January 2013, 40 uremic patients with renal allograft in the organ transplantation department were divided into two groups according to the recovery of renal function after renal transplantation, and 20 patients with renal allograft dysfunction were included in the injury group. Twenty patients with normal renal function after renal transplantation were admitted into the non-injuried group and 20 healthy persons as the control group. The levels of OPG and MIG were measured at 0, 1, 2, 3, 5, 7 days after operation. Results: the levels of OPG and MIG in the injured group were significantly higher than those in the non-injured group (79 卤13) ng/L, (514.3 卤79.8) ng/L, and (3.6 卤1.89) ng/L, (86.8 卤19.36) ng/L, in the non-injured group, and those in the non-injured group were significantly higher than those in the control group. The difference was statistically significant (P0.01); (86.8 卤19.36) ng/L in the non-injury group was significantly different from (13.2 卤5.33) ng/L,MIG in the control group (P0.05), but there was no significant difference in OPG between the two groups (P0.05). Conclusion: the expression of OPG,MIG in different degrees of urine after renal transplantation has shown its potential value as a biomarker and may be a relevant laboratory index for evaluating renal allograft injury.
【作者单位】：郑州人民医院器官移植科;

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