腹腔镜肾部分切除与肾切除对小型猪肝肾功能的影响

发布时间：2019-05-08 19:03

【摘要】：本试验旨在比较腹腔镜下肾部分切除与肾切除对小型猪肝肾功能的影响,评估手术的安全性与可行性,为两种手术方法的应用提供科学依据。试验以10头广西巴马小型猪为研究对象,随机分为腹腔镜肾部分切除术组(LPN组)与腹腔镜肾切除术组(LRN组),分别于术前、术后即刻、术后1d、2d、3d、5d、7d、14d采取前腔静脉血,检测肝功能指标丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST),肾功能指标β2微球蛋白(β2-MG)、肾损伤分子-1(KIM-1)、胱抑素C(CYS-C),比较其差异性。结果显示,两组手术均成功完成,肝、肾功能指标均呈先升高后降低趋势,与试验前相比差异极显著(P0.01)。LPN组术后肝功能指标高于LRN组,差异极显著(P0.01);LPN组术后肾功能指标略高于LRN组,无显著性差异(P0.05),LPN组肾功能指标恢复至术前水平更快速。结果表明,LPN较LRN在短期内会造成更严重的肝肾损伤,但更有利于肾功能恢复,临床上应依据不同情况进行选择。
[Abstract]:The purpose of this study was to compare the effects of laparoscopic partial resection of kidney and kidney resection on liver and kidney function in miniature pigs, to evaluate the safety and feasibility of the operation, and to provide scientific basis for the application of the two surgical methods. Ten Guangxi Bama miniature pigs were randomly divided into laparoscopic partial renectomy group (LPN group) and laparoscopic renectomy group (LRN group). Before, immediately, 1 day, 3 days, 5 days and 7 days after operation, respectively. The renal function indexes 尾 2-microglobulin (尾 2-MG), renal injury molecule-1 (KIM-1), cystatin C (CYS-C) were measured for alanine transaminase (ALT), aspartate aminotransferase (AST),) and renal function index (尾 _ 2-microglobulin) in anterior vena cava blood for 14 days. Compare their differences. The results showed that the liver and kidney function indexes in the two groups were increased first and then decreased, and there was a significant difference compared with the pre-test group (P0.01). The liver function index in). LPN group was higher than that in LRN group after operation (P0.01). The renal function index of LPN group was slightly higher than that of LRN group after operation, and there was no significant difference (P 0.05). The recovery of renal function index to preoperative level was faster in), LPN group. The results showed that LPN would cause more serious liver and kidney injury than LRN in a short period of time, but it was more beneficial to the recovery of renal function.
【作者单位】：东北农业大学动物医学学院;
【基金】：基金项目:实验动物学与比较医学动物模型平台建设(PC13S12)
【分类号】：R699.2

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