肾脏原发性神经内分泌肿瘤4例临床病理学观察
发布时间：2019-05-18 10:25
【摘要】：目的探讨肾脏原发性神经内分泌肿瘤(primary renal neuroendocrine tumors,PRNET)的临床病理学特征。方法对4例PRNET切除标本行HE染色、免疫组化染色,电镜下观察其形态结构、免疫表型及超微结构特点,并复习相关文献。结果4例PRNET中3例男性,1例女性;年龄39~73岁,平均50岁。2例PRNET因腰背部疼痛就诊,2例PRNET患者体检发现入院。4例PRNET镜下结构相似,肿瘤细胞呈管状、条带状紧密排列生长,部分呈巢、团状;肿瘤细胞规则一致,核深染,染色质细腻,核仁不易见,核分裂象均㩳3个/10 HPF。免疫表型:4例Syn均呈强阳性,2例Cg A呈阳性,2例CKpan呈局灶阳性,1例P504S呈阳性;CD10、CD117、PAX2、PAX8、PLAP、Ksp-cadherin均阴性;Ki-67增殖指数1%~5%。1例PRNET于电镜下见胞质内有大量神经内分泌颗粒,细胞间有桥粒连接。结论 PRNET是一种罕见的肾脏肿瘤,可发生于肾脏任何部位,无明显性别差异。诊断多依靠病理学检查,并结合免疫表型,必要时辅助电镜技术以明确诊断。
[Abstract]:Objective to investigate the clinicopathological features of primary renal neuroendocrine tumor (primary renal neuroendocrine tumors,PRNET. Methods HE staining, immunohistochemical staining and electron microscope were performed in 4 cases of PRNET resected specimens. The morphological structure, immunophenotypic and ultrastructure characteristics were observed under electron microscope, and the related literatures were reviewed. Results among the 4 cases of PRNET, 3 cases were male and 1 case was female. The age was 39 鈮，
本文编号：2479916
[Abstract]:Objective to investigate the clinicopathological features of primary renal neuroendocrine tumor (primary renal neuroendocrine tumors,PRNET. Methods HE staining, immunohistochemical staining and electron microscope were performed in 4 cases of PRNET resected specimens. The morphological structure, immunophenotypic and ultrastructure characteristics were observed under electron microscope, and the related literatures were reviewed. Results among the 4 cases of PRNET, 3 cases were male and 1 case was female. The age was 39 鈮，
本文编号：2479916
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