利拉鲁肽对糖尿病肾病患者炎症因子影响的研究进展

发布时间：2019-06-29 20:16

【摘要】：目的:了解利拉鲁肽对糖尿病肾病患者炎症因子影响的研究进展。方法:查阅近年来国内外相关文献,就利拉鲁肽的作用机制和对糖尿病肾病患者炎症因子的影响进行归纳和总结。结果与结论:利拉鲁肽是胰高糖素样肽-1的类似物,作用机制广泛,具有保护胰岛B细胞、降低血糖、减轻体质量、保护心脏和抑制炎症反应等作用。利拉鲁肽抑制糖尿病肾病炎症因子表现为下调肿瘤坏死因子-α在机体的表达,减轻氧化应激反应;作用于血管紧张素(AngⅡ)-1受体和AngⅡ-2受体,改善AngⅡ对肾的损伤;降低白细胞介素(IL)-1β,改善胰岛功能;下调血清中的IL-6水平等。对利拉鲁肽延缓肾损害的深入研究将为其用于糖尿病肾病的临床治疗提供有力的支持。
[Abstract]:Objective: to investigate the effect of Lilaruin on inflammatory factors in patients with diabetic nephropathy. Methods: the mechanism of Lilarubicin and its effect on inflammatory factors in patients with diabetic nephropathy were summarized by reviewing the relevant literature at home and abroad in recent years. Results and conclusion: Lilarubicin is a similar substance of glucagon-like peptide-1, which has a wide range of mechanisms. It can protect islet B cells, reduce blood glucose, reduce body mass, protect the heart and inhibit inflammatory reaction. Lilaruin can inhibit the expression of tumor necrosis factor-伪 in diabetic nephropathy by down-regulating the expression of tumor necrosis factor-伪 in the body and reducing oxidative stress. It acts on angiotensin (Ang 鈪，

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